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CML at the 2018 ASH meeting—selected presentations

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Summary

Treatment recommendations in chronic myeloid leukemia (CML) treatment have not changed substantially since treatment-free remission (TFR) has become a therapeutic option. Hence, allowing more patients to enter TFR is gaining significance. Although, Asciminib as a first-in-class new type of tyrosine kinase inhibitor (TKI) is in clinical development, currently combination treatment with TKIs and Interferon-alpha2b appears the best option to deepen molecular response and broaden the basis of potential TFR candidates. Improving the chances of a first successful TFR has to be the primary goal in TFR optimization as even re-induction of a deep molecular response after TFR failure using second generation TKIs shows disillusioning results.

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Funding

The author received research grants and/or honoraria from Incyte, Pfizer, BMS, AOP, Novartis.

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  1. Department of Hematology and Oncology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria

    Stefan Schmidt

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  1. Stefan Schmidt
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Correspondence to Stefan Schmidt.

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S. Schmidt declares that he has no competing interests.

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Schmidt, S. CML at the 2018 ASH meeting—selected presentations. memo 12, 196–199 (2019). https://doi.org/10.1007/s12254-019-00529-4

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