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JAK2V617F allele burden: innovative concept in monitoring of myeloproliferative neoplasms

  • Soheila Bagheropur
  • Ali Ehsanpour
  • Maryam Tahmasebi Birgani
  • Najmaldin Saki
review
  • 37 Downloads

Summary

Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by mutations in genes, such as JAK2V617F, JAK2 exon12 gene and MPL. With respect to MPN-associated subclasses, each of these disorders has a different allele burden during disease treatment. Up to now, several studies have been conducted on the relationship between allele burden with specific MPN-associated phenotypic features, prognosis and disease progression. It seems that finding such a correlation would be a great contribution to faster diagnosis and effective treatment. The goal of this review is to investigate the relationship between JAK2V617 allele burden with different MPN subtypes and their different phenotypes. Allele burden is closely associated with MPN phenotype and can partially indicate the prognosis, progression and even the likelihood of disease transformation.

Keywords

Allele burden JAK2 Myeloproliferative disorders 

Notes

Acknowledgements

This study is part of M.Sc thesis for Soheila Bagherpour. Special thanks to Ahvaz Jundishapur University of Medical Sciences for the financial support.

Compliance with ethical guidelines

Conflict of interest

S. Bagheropur, A. Ehsanpour, M.T. Birgani, and N. Saki declare that they have no competing interests.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Soheila Bagheropur
    • 1
  • Ali Ehsanpour
    • 1
  • Maryam Tahmasebi Birgani
    • 2
  • Najmaldin Saki
    • 1
  1. 1.Thalassemia & Hemoglobinopathy Research Center, Research Institute of HealthAhvaz Jundishapur University of Medical SciencesAhvazIran
  2. 2.Department of Medical Genetics, School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

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