JAK2V617F allele burden: innovative concept in monitoring of myeloproliferative neoplasms
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Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by mutations in genes, such as JAK2V617F, JAK2 exon12 gene and MPL. With respect to MPN-associated subclasses, each of these disorders has a different allele burden during disease treatment. Up to now, several studies have been conducted on the relationship between allele burden with specific MPN-associated phenotypic features, prognosis and disease progression. It seems that finding such a correlation would be a great contribution to faster diagnosis and effective treatment. The goal of this review is to investigate the relationship between JAK2V617 allele burden with different MPN subtypes and their different phenotypes. Allele burden is closely associated with MPN phenotype and can partially indicate the prognosis, progression and even the likelihood of disease transformation.
KeywordsAllele burden JAK2 Myeloproliferative disorders
This study is part of M.Sc thesis for Soheila Bagherpour. Special thanks to Ahvaz Jundishapur University of Medical Sciences for the financial support.
Compliance with ethical guidelines
Conflict of interest
S. Bagheropur, A. Ehsanpour, M.T. Birgani, and N. Saki declare that they have no competing interests.
This article does not contain any studies with human participants or animals performed by any of the authors.
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