Cell free nucleic acids as diagnostic and prognostic marker in leukemia
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Nucleic acids in circulation, called cell free DNA (cfDNA) and cell free RNA (cfRNA), have recently been analyzed as suitable diagnostic and prognostic markers in cancer. There have also been several reports about the role of this type of marker in leukemia. The relevant literature was identified by a PubMed search (2000–2017) of English-language literature using the terms “cell free DNA”, “Leukemia” and Micro-RNA. Many quantitative and qualitative cfDNA biomarkers including copy number alteration, mutation, LOH and micro-RNA deregulated expression have been investigated in different studies, indicating promising results to distinguish patients from healthy individuals. The findings of this study indicate that nucleic acids in circulation have a high diagnostic and prognostic value in leukemic patients and, thus, have the potential to be used alongside the usual methods in the management of this disease.
KeywordsNucleic acids Leukemia Diagnosis Prognosis
We wish to thank all our colleagues in Golestan Hospital’s Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences.
Compliance with ethical guidelines
Conflict of interest
M. Eini, S.A. Nojoumi, M.-A. Saki, and A. Khosravi declare that they have no competing interests.
This article does not contain any studies with human participants or animals performed by any of the authors.
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