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memo - Magazine of European Medical Oncology

, Volume 9, Issue 1, pp 48–51 | Cite as

8-year-sustained response in a patient with isolated del(5q) myelodysplastic syndrome undergoing continuous treatment with lenalidomide: a case report

  • Martin FarkasEmail author
case report

Abstract

The advent of lenalidomide has fundamentally changed the treatment of patients with myelodysplastic syndrome (MDS) and deletion of the long arm of chromosome 5 (del(5q)), inducing high rates of red blood cell transfusion independence and cytogenetic response. We report a case of an 84-year-old patient with International Prognostic Scoring System (IPSS)-defined low-risk MDS with isolated del(5q), who has received continuous lenalidomide treatment for the past 8 years and whose treatment is ongoing. Grade 3 or 4 neutropenia and thrombocytopenia, which occurred in approximately 60 % of the patients during the first weeks of treatment, did not occur in our patient. Also, there were no thromboembolic events or a progression to acute myeloid leukemia. This case highlights the role of lenalidomide in modifying the course of low-risk del(5q) MDS in long-term responders by inducing a durable hematologic response and thereby contributing to control iron overload and improving long-term outcomes in selected patients.

Keywords

Myelodysplastic syndrome MDS with deletion of chromosome 5q del(5q) MDS Lenalidomide Long-term transfusion independence 

Schlüsselwörter

Myelodysplastisches Syndrom MDS mit Deletion am Chromosom 5q del(5q) MDS Lenalidomid Transfusionsunabhängigkeit 

Notes

Acknowledgments

Editorial support for the preparation of the manuscript was provided by Gabriele Berghammer, the text clinic, and funded by Celgene Corporation. The author is fully responsible for the content and editorial decisions related to this manuscript.

Conflict of interest

Martin Farkas declares that there are no actual or potential conflicts of interest in relation to this article.

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Division for Hemato-Oncology, 1st Department for Internal MedicineLandesklinikum Wiener NeustadtWiener NeustadtAustria

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