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High-dose chemotherapy and autologous hematopoietic stem cell transplantation in a myeloma patient with terminal renal failure and hepatitis C with high viral load

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Abstract

We report on a patient with multiple myeloma and light-chain induced renal failure, diagnosed with hepatitis C and high viral load in the pre-transplant period. We show that the new hepatitis C virus directed drugs daclatasvir and sofosbuvir can be safely applied concomitantly to high-dose therapy with autologous hematopoietic stem cell transplantation. Liver enzymes remained in the normal range during the transplant and in the post-transplant period.

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Conflict of interest

Michael Gschwantler is advisor for Janssen, Vertex/Tibotec, MSD, BMS, AbbVie, Gilead and GlaxoSmithKline Pharma. He has also served as speaker for Janssen, Roche Austria, Vertex/Tibotec, MSD, BMS, AbbVie, Gilead and GlaxoSmithKline Pharma. The other authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Medicine I, Center for Oncology, Hematology and Outpatient Clinic and Palliative Care, Wilhelminenspital, Montleartstr. 37, 1160, Vienna, Austria

    Niklas Zojer & Wolfgang Hilbe

  2. Department of Medicine IV, Gastroenterology and Hepatology, Wilhelminenspital, Vienna, Austria

    Michael Gschwantler

Authors
  1. Niklas Zojer
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  2. Michael Gschwantler
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  3. Wolfgang Hilbe
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Correspondence to Niklas Zojer.

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Zojer, N., Gschwantler, M. & Hilbe, W. High-dose chemotherapy and autologous hematopoietic stem cell transplantation in a myeloma patient with terminal renal failure and hepatitis C with high viral load. memo 8, 35–37 (2015). https://doi.org/10.1007/s12254-015-0198-4

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  • DOI: https://doi.org/10.1007/s12254-015-0198-4

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