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ASH 2012 update chronic lymphocytic leukemia—the best is yet to come

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Abstract

Treatment of CLL has been significantly improved through combination of chemotherapy and rituximab. Furthermore, the positive influence of MRD negativity on survival was clearly demonstrated. More recently, drugs with novel modes of action, e.g. targeting B-cell receptor or downstream, chemotherapy-free therapy concepts seem to possible in the near future. More importantly, administration of new drugs with the aim to overcome unfavorable prognostic factors as 17p- or BIRC3, NOTCH1 and SF3B1 is warranted.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine with Hematology, Medical Oncology, Hemostaseology, Infectious Disease, Rheumatology, Oncologic Center, Laboratory for Immunological and Molecular Cancer Research, Salzburger Landeskliniken, Paracelsus Medical University Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Austria

    Lukas Weiss, Thomas Melchardt, Richard Greil & Georg Hopfinger

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  1. Lukas Weiss
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  2. Thomas Melchardt
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  4. Georg Hopfinger
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Correspondence to Georg Hopfinger.

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Weiss, L., Melchardt, T., Greil, R. et al. ASH 2012 update chronic lymphocytic leukemia—the best is yet to come. memo 6, 177–180 (2013). https://doi.org/10.1007/s12254-013-0099-3

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  • DOI: https://doi.org/10.1007/s12254-013-0099-3

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