Summary
Gastric cancer is still a devastating disease. Two thirds of the patients are diagnosed in a locally advanced or metastatic stage. Even if surgery is possible, long-term survival is low. Optimal therapy in a curative and a palliative setting is still not clear yet. ASCO 2010 could shed some light on optimal chemotherapy and the introduction of molecular targeted therapy. The aim of this article is to summarize the most important publications at this year's ASCO annual meeting and to put them into context of current therapeutic strategies.
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Ronellenfitsch U, Schwarzbach M, Hofheinz R, Kienle P, Hohenberger P, Jensen K, Kieser M, Slanger TE. GE Adenocarcinoma Meta-analysis Group: Meta-analysis of preoperative chemotherapy (CTX) versus primary surgery for locoregionally advanced adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus (GE adenocarcinoma). J Clin Oncol, 28: 15s, 2010 (suppl; abstr 4022)
Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med, 355: 11–20, 2006
Boige V, Pignon J, Saint-Aubert B, et al. Final results of a randomized trial comparing preoperative 5-fluorouracil (F)/cisplatin (P) to surgery alone in adenocarcinoma of stomach and lower esophagus (ASLE): FNLCC ACCORD07-FFCD 9703 trial. J Clin Oncol, 25: 18s 2007: abstract (4510)
Wöll E, DeVries A, Eisterer W. et al. Chemotherapy in gastric cancer. Anticancer Res, 28: 1213–1220, 2008
Okines F, Langley R, Cafferty FH, Stenning SP, Falk S, seymour MT, Smith D, Middleton GW, Coxon FY, Cunningham D. Preliminary safety data from a randomized trial of perioperative epirubicin, cisplatin plus capecitabine (ECX) with or without bevacizumab (B) in patients (pts) with gastric or oesophagogastric junction (OGJ) adenocarcinoma. J Clin Oncol, 28: 15s, 2010 (suppl; abstr 4019)
Lorenzen S, Panzram B, Rosenberg R, Becker K, Schenk U, Höfler H, Siewert JR, Ott K; Prognostic significance of free peritoneal tumor cells in the peritoneal cavity before and after neoadjuvant chemotherapy in patients with gastric cancer undergoing a potentially curative resection. J Clin Oncol. 28: 15s, 2010 (suppl; abstr 4156)
Shah MA, Shibata S, Stoller RG, Kemeny M, Ritch PS, Krishnamurthi SS, Su YB, Janjigian YY, Capanu M, Kelsen DP. Random assignment multicenter phase II study of modified docetaxel, cisplatin, fluorouracil (mDCF) versus DCF with growth factor support (GCSF) in metastatic gastroesophageal adenocarcinoma (GE). J Clin Oncol 28: 15s, 2010 (suppl; abstr 4014)
Al-Batran S, Homann N, Hartmann JT, Moehler MH, Pauligk C, Probst S, Rethwisch V, Prasnikar N, Stoehlmacher J, Jaeger E. 5-fluorouracil, leucovorin, and oxaliplatin with or without docetaxel in elderly (65 years or older) patients with esophagogastric cancer: FLOT65+ trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). J Clin Oncol, 28: 15s, 2010 (suppl; abstr 4013)
Thuss-Patience PC, et al. Irinotecan versus best supportive care (BSC) as second-line therapy in gastric cancer: A randomized phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO) J Clin Oncol, 27: 15s, 2009 (suppl; abstr 4540)
Takashima A, Boku N, Kato K, Mizusawa J, Nakamura K, Fukuda H, Shirao K, Shimada Y, Ohtsu A. Survival prolongation after treatment failure in patients with advanced gastric cancer (AGC): results from combined analysis of JCOG9205 and JCOG9912. J Clin Oncol, 28: 15s, 2010 (suppl; abstr 4061)
Van Cutsem E, et al: Efficacy results from the ToGA trial: a phase III study of trastuzumab added to standard chemotherapy in first-line HER2-positive advanced gastric cancer. J Clin Oncol, 27: 15s, 2009 (suppl; abstr LBA4511)
Chung HC, Bang Y, Van Cutsem E, Kang Y, Hamamoto Y, Moiseyenko V, Gotovkin E, Urspruch A, Ducournau P. (Q)-TWiST analysis of trastuzumab plus fluoropyrimidine/cisplatin (T-XP/FP) versus XP/FP alone as first-line therapy for advanced HER2-positive gastric cancer. J Clin Oncol, 28: 15s, 2010 (suppl; abstr 4048)
Kang Y, Ohtsu A, Van Cutsem E, Rha SY, Sawaki A, Park S, Lim H, Wu J, Langer B, Shah MA. AVAGAST: a randomized, double-blind, placebo-controlled, phase III study of first-line capecitabine and cisplatin plus bevacizumab or placebo in patients with advanced gastric cancer (AGC). J Clin Oncol, 28: 18s, 2010 (suppl; abstr LBA4007)
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Wöll, E. Gastric cancer – ASCO 2010. memo 3, 168–170 (2010). https://doi.org/10.1007/s12254-010-0230-7
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DOI: https://doi.org/10.1007/s12254-010-0230-7