Summary
Treatment of thymomas remains a challenge for oncologists as no clear evidence-based guidelines can be provided due to the lack of randomized trials. Whenever possible, surgical removal of all gross tumour remains the mainstay of every therapeutic concept. Nevertheless, despite optimal surgery, there remains a clinically relevant risk for recurrence, inevitably posing the question concerning the value of adjuvant or neoadjuvant treatment-interventions. The following short review aims to provide concise information on the available data on neoadjuvant and adjuvant radiotherapy and/or chemotherapy in patients with thymoma, thus supporting the treating physician in advising their patients and finally reaching an informed consent.
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References
Rosai J. Histological typing of tumors of the thymus, 2nd edn. New York Berlin: Springer, 1999
Kondo K, Yoshizawa K, Tsuyuguchi M, et al. WHO histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg, 77: 1183–1188, 2004
Engels EA, Pfeiffer RM. Malignant thymoma in the united states: demographic patterns in incidence and associations with subsequent malignancies. Int J Cancer, 105: 546–551, 2003
Masaoka A, Monden Y, Nakahana K, et al. Follow-up study of thymomas with special references to their clinical stages. Cancer, 48: 2485–2492, 1981
Kondo K, Yasumasa M. Therapy for thymic epithelial tumors: a clinical study of 1320 patients from Japan. Ann Thorac Surg, 76: 878–884, 2003
Maggi G, Casadio C, Cavallo A, et al. Thymoma: results of 241 operated cases. Ann Thorac Surg, 51: 152–156, 1991
Blumberg D, Port J, Webster B, et al. Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg, 60: 908–914, 1995
Curran WJ Jr, Kornstein MJ, Brooks JJ, et al. Invasive thymoma: the role of mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol, 6: 1722–1727, 1988
Ogawa K, Uno T, Toita T, et al. Postoperative radiotherapy for patients with completely resected thymoma: a multi-institutional, retrospective review of 103 patients. Cancer, 94: 1405–1413, 2002
Haniuda M, Morimoto M, Nishimura H, et al. Adjuvant radiotherapy after complete resection of thymoma. Ann Thorac Surg, 54: 311–315, 1992
Regnard JF, Magdeleinat P, Dromer C, et al. Prognostic factors and long-term results after thymoma resection: a series of 307 patients. J Thorac Cardiovasc Surg, 112: 376–384, 1996
Monden Y, Nakahara K, Iioka S, et al. Recurrence of thymoma: clinicopathological features, therapy, and prognosis. Ann Thorac Surg, 39: 165–169, 1985
Venuta F, Rendina EA, Longo F, et al. Long-term outcome after multimodality treatment for stage III thymic tumors. Ann Thorac Surg, 76: 1866–1872, 2003
Kim ES, Putnam JB, Komaki R, et al. Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report. Lung Cancer, 44: 369–379, 2006
Strobel P, Bauer A, Puppe B, et al. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J Clin Oncol, 22: 1501–1509, 2004
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Pall, G. (Neo-)Adjuvant treatment of malignant thymoma. memo 1, 67–69 (2008). https://doi.org/10.1007/s12254-008-0022-5
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DOI: https://doi.org/10.1007/s12254-008-0022-5