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Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis

  • Original Article
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Pathology & Oncology Research

Abstract

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis and low survival. To date, only 67 cases have been described in the English language literature, and an understanding of the behavior of CCOC has been based on limited case reports. The aim of the research was to further reveal the features of CCOC. We report 5 new cases of CCOC, with a mean age of 52.4 years. The clinical and histopathologic data of the disease obtained from earlier literature (95 cases) and the 5 new cases were analyzed. Data were extracted, including demographics, histopathologic findings, clinical presentation, primary treatment and outcomes. Immunohistochemical results revealed that the cancer is positive for AE1/AE3, EMA and CK19, negative for smooth muscle actin SMA, Vim and S-100. EWSR1 translocation was also observed in the new cases, which may help in the diagnosis of CCOC. Metastases of CCOC were rare, but the local recurrence rate of CCOC rose to 42%. The best treatment for patients with CCOC is wide local excision combined with regional lymph node dissection.

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Author notes

  1. Liu Liu and Jin-Wei Zhang contributed equally to this work.

Authors and Affiliations

  1. Department of Oral and Maxillofacial-Head & Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Liu Liu, Yun Zhu & Bing Guo

  2. Department of Stomatology, Branch of Tianjin Third Central Hospital, Tianjin, 300000, China

    Jin-Wei Zhang

  3. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210000, Jiangsu, China

    Ni-Sha Zhu

  4. Department of Oral and Maxillofacial Surgery, affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, China

    Xi-Hu Yang

Authors
  1. Liu Liu
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  2. Jin-Wei Zhang
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  3. Ni-Sha Zhu
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  4. Yun Zhu
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  5. Bing Guo
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Contributions

Conceived and designed the experiment: XHY LL BG. Performed the experiments: JWZ NSZ. Analyzed the data: XHY LL. Materials/Analysis tools: XHY. Wrote the paper XHY LL JWZ.

Corresponding authors

Correspondence to Bing Guo or Xi-Hu Yang.

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Competing Interests

All authors declare that there are no potential conflicts of interest.

Grant Support

This study was supported by Jiangsu Province’s Key Provincial Youth Talents Program (Grant No.QNRC2016841).

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Liu, L., Zhang, JW., Zhu, NS. et al. Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis. Pathol. Oncol. Res. 26, 1559–1564 (2020). https://doi.org/10.1007/s12253-019-00741-x

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  • DOI: https://doi.org/10.1007/s12253-019-00741-x

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