KIBRA Team Up with Partners to Promote Breast Cancer Metastasis

Abstract

Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized by many genetic aberrations including mutations, overexpression of oncogenes etc. KIBRA (KIdney/BRAin protein), a scaffolding protein is recently described as an important player in the process of invasion and metastasis. The Kidney/BRAin protein through its different domains interacts with various proteins to couple cytoskeleton arrangement, cell polarity and migration. N terminal and C terminal of the protein contains the WW, Internal C2 & putative class III PDZ domain that interacts with DDR1, DLC1 & PKCζ. These protein-protein interactions equip the breast cancer cells to invade and metastasize. Here, we discuss a comprehensive knowledge about the KIBRA protein, its domains and the interacting partners involved in metastasis of breast cancer.

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Acknowledgements

Authors acknowledge DST- SERB, Government of India for extramural funding (EMR/2015/000761) to HC.

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Correspondence to Harish Chander.

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Singh, G., Mishra, S. & Chander, H. KIBRA Team Up with Partners to Promote Breast Cancer Metastasis. Pathol. Oncol. Res. 26, 627–634 (2020). https://doi.org/10.1007/s12253-019-00660-x

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Keywords

  • Breast Cancer
  • Metastasis
  • Kibra
  • DDR1
  • DLC1 & PKCζ