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Prognostic Value of Progranulin in Patients with Colorectal Cancer Treated with Curative Resection

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Pathology & Oncology Research

Abstract

Progranulin (PGRN) has been characterized as an autocrine growth and survival factor and is known to stimulate tumorigenesis and proliferation of several types of cancer cell. However, little is known about the prognostic role of PGRN in colorectal cancer (CRC). A retrospective analysis was performed for patients with colorectal cancer who underwent curative resection between May 2013 and June 2015. PGRN expression in tumor cells was semi-quantitatively categorized (no expression, 0; weak/focal, 1+; moderate/focal or diffuse, 2+; strong/diffuse, 3+), and high expression was considered for tumors graded ≥2+ staining intensity. A total of 109 patients (28 stage I, 32 stage II, and 49 stage III) were analyzed. Thirty-eight patients (35%) had tumors with high PGRN expression, and there was a trend of elevated pre-operative CEA and CA19–9 levels in patients with high PGRN-expressing tumors compared to those with low PGRN-expressing tumors (CEA, 49% vs. 21%; CA19–9, 21% vs. 7%). The 3–year recurrence-free survival (3Y–RFS) and overall survival rates were 83.7% (95% CI, 76.8–90.6) and 96.0% (95% CI, 92.3–99.7), respectively. Patients with high PGRN-expressing tumors had a worse rate of 3Y–RFS (66.8%) compared to those with low PGRN-expressing tumors (92.4%; p = 0.010). Multivariate analysis showed that high PGRN expression, age (>66 years), stage (III), and perineural invasion (+) were independent prognostic factors associated with poor RFS after adjusting for confounding factors including sex, MSI, tumor location, KRAS, and lympho-vascular invasion. PGRN overexpression was significantly associated with poor RFS in patients with CRC who have undergone curative resection.

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Funding

This work was supported by the Medical Research Funds from Kangbuk Samsung Hospital (Seoul, Korea).

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Author notes

  1. D-H Koo and I-G Do contributed equally to the work as first authors.

  2. S Oh and H Kim contributed equally to the work as corresponding authors.

Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea

    Dong-Hoe Koo, Sukjoong Oh & Yun-Gyoo Lee

  2. Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

    In-Gu Do, Kyungeun Kim & Jin Hee Sohn

  3. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Soo-Kyung Park, Hyo-Joon Yang, Yoon Suk Jung & Dong Il Park

  4. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea

    Kyung Uk Jeong, Hyung Ook Kim, Hungdai Kim & Ho-Kyung Chun

  5. A&G Pharmaceutical, Inc., Columbia, MD, USA

    Ginette Serrero

  6. Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA

    Ginette Serrero

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  1. Dong-Hoe Koo
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On Behalf of the KBSMC Colorectal Cancer Team

Corresponding authors

Correspondence to Sukjoong Oh or Hungdai Kim.

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Conflict of Interest

The authors have no conflicts of interest to declare, except of GS who is an employee of A&G Pharmaceutical.

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Koo, DH., Do, IG., Oh, S. et al. Prognostic Value of Progranulin in Patients with Colorectal Cancer Treated with Curative Resection. Pathol. Oncol. Res. 26, 397–404 (2020). https://doi.org/10.1007/s12253-018-0520-7

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  • DOI: https://doi.org/10.1007/s12253-018-0520-7

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