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Primary Osteosarcoma of the Liver: Case Report and Literature Review

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Pathology & Oncology Research

Abstract

Extraskeletal osteosarcoma is a rare, highly malignant, osteoid formation mesenchymal neoplasm in the absence of bone involvement, associated with exceptionally poor prognosis. It frequently arises in the soft tissues of the extremities or in the retroperitoneum, but rarely in visceral organ. We describe a primary osteosarcoma of the liver in a 70-year-old man who presented with an episode of fever, accompanied by abdominal discomfort, after an accident abdominal strike. Ultrasonography and computed tomography revealed a large heterogeneous mass with areas of dense calcification involving most of the right lobe of liver. Radiography did not show evidence of primary tumor or primary bone lesion at any other site. Histologically, the tumor showed an essentially similar appearance as osteosarcoma originating in the skeleton, comprised of polygonal or spindle shaped cells, along with abundant eosinophilic lace-like osteoids, or irregularly arranged bone trabeculae. Immunohistochemistry showed that the tumor cells were positive for vimentin, CD10, and focally for SMA and CD56, but negative for other lineage-specific markers. Thus, the findings favored a primary hepatic osteosarcoma. This patient received palliative chemotherapy to ease the signs of his sickness due to the large size of the tumor and he died 4 moths later.

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References

  1. Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, Ayala AG (1990) Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases. Cancer 65(12):2762–2770

    Article  CAS  Google Scholar 

  2. Chung EB, Enzinger FM (1987) Extraskeletal osteosarcoma. Cancer 60(5):1132–1142

    Article  CAS  Google Scholar 

  3. Lee JS, Fetsch JF, Wasdhal DA, Lee BP, Pritchard DJ, Nascimento AG (1995) A review of 40 patients with extraskeletal osteosarcoma. Cancer 76(11):2253–2259

    Article  CAS  Google Scholar 

  4. Lidang Jensen M, Schumacher B, Myhre Jensen O, Steen Nielsen O, Keller J (1998) Extraskeletal osteosarcomas: a clinicopathologic study of 25 cases. Am J Surg Pathol 22(5):588–594

    Article  CAS  Google Scholar 

  5. McCarter MD, Lewis JJ, Antonescu CR, Brennan MF (2000) Extraskeletal osteosarcoma: analysis of outcome of a rare neoplasm. Sarcoma 4(3):119–123

    Article  CAS  Google Scholar 

  6. Allan CJ, Soule EH (1971) Osteogenic sarcoma of the somatic soft tissues. Clinicopathologic study of 26 cases and review of literature. Cancer 27(5):1121–1133

    Article  CAS  Google Scholar 

  7. Hoch M, Ali S, Agrawal S, Wang C, Khurana JS (2013) Extraskeletal osteosarcoma: a case report and review of the literature. J Radiol Case Rep 7(7):15–23

    PubMed  PubMed Central  Google Scholar 

  8. Govender D, Rughubar KN (1998) Primary hepatic osteosarcoma: case report and literature review. Pathology 30(3):323–325

    Article  CAS  Google Scholar 

  9. Maynard JH, Fone DJ (1969) Haemochromatosis with osteogenic sarcoma in the liver. Med J Aust 2(25):1260–1263

    Article  CAS  Google Scholar 

  10. Sumiyoshi A, Niho Y (1971) Primary osteogenic sarcoma of the liver--report of an autopsy case. Acta Pathol Jpn 21(2):305–312

    CAS  PubMed  Google Scholar 

  11. von Hochstetter AR, Hattenschwiler J, Vogt M (1987) Primary osteosarcoma of the liver. Cancer 60(9):2312–2317

    Article  Google Scholar 

  12. Craig JR, Peters RL, Edmondson HA (1989) Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. Armed Forces Institute of Pathology, Washington, pp 223–255

    Google Scholar 

  13. Kitayama Y, Sugimura H, Arai T, Nagamatsu K, Kino I (1995) Primary osteosarcoma arising from cirrhotic liver. Pathol Int 45(4):320–325

    Article  CAS  Google Scholar 

  14. Krishnamurthy VN, Casillas VJ, Bejarano P, Saurez M, Franceschi D (2004) Primary osteosarcoma of liver. European Journal of Radiology Extra 50(1):31–36

    Article  Google Scholar 

  15. Park SH, Choi SB, Kim WB, Song TJ (2009) Huge primary osteosarcoma of the liver presenting an aggressive recurrent pattern following surgical resection. J Dig Dis 10(3):231–235

    Article  Google Scholar 

  16. Nawabi A, Rath S, Nissen N, Forscher C, Colquhoun S, Lee J, Geller S, Wong A, Klein AS (2009) Primary hepatic osteosarcoma. J Gastrointest Surg 13(8):1550–1553

    Article  Google Scholar 

  17. Jiang RD, Zhang ZL, Li T (2015) Abdominal pain caused by spontaneous rupture of a liver tumor. Gastroenterology 149(1):35–36

    Article  Google Scholar 

  18. Tamang TG, Shuster M, Chandra AB (2016) Primary hepatic osteosarcoma: a rare cause of primary liver tumor. Clin Med Insights Case Rep 9:31–33

    Article  Google Scholar 

  19. Mechtersheimer G, Moller P (1989) Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. Am J Pathol 134(5):961–965

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Hasegawa T, Hirose T, Kudo E, Hizawa K, Usui M, Ishii S (1991) Immunophenotypic heterogeneity in osteosarcomas. Hum Pathol 22(6):583–590

    Article  CAS  Google Scholar 

  21. Ojima A, Sugiyama T, Takeda T, Hazama F, Nakakuki F, Uesugi Y et al (1964) Six cases of rare malignant tumors of the liver. Acta Pathol Jpn 14:95–102

    CAS  PubMed  Google Scholar 

  22. Leger-Ravet MB, Borgonovo G, Amato A, Lemaigre G, Franco D (1996) Carcinosarcoma of the liver with mesenchymal differentiation: a case report. Hepato-Gastroenterology 43(7):255–259

    CAS  PubMed  Google Scholar 

  23. Carter R (1969) Hepatoblastoma in the adult. Cancer 23(1):191–197

    Article  CAS  Google Scholar 

  24. Haratake J, Horie A (1991) An immunohistochemical study of sarcomatoid liver carcinomas. Cancer 68(1):93–97

    Article  CAS  Google Scholar 

  25. Kakizoe S, Kojiro M, Nakashima T (1987) Hepatocellular carcinoma with sarcomatous change. Clinicopathologic and immunohistochemical studies of 14 autopsy cases. Cancer 59(2):310–316

    Article  CAS  Google Scholar 

  26. Stout AP (1948) Mesenchymoma, the mixed tumor of mesenchymal derivatives. Ann Surg 127(2):278–290

    Article  CAS  Google Scholar 

  27. Heukamp LC, Knoblich A, Rausch E, Friedrichs N, Schildhaus HU, Kahl P, Tismer R, Schneider B, Büttner R, Houshdaran F (2007) Extraosseous osteosarcoma arising from the small intestinal mesentery. Pathol Res Pract 203(6):473–477

    Article  CAS  Google Scholar 

  28. Sordillo PP, Hajdu SI, Magill GB, Golbey RB (1983) Extraosseous osteogenic sarcoma. A review of 48 patients. Cancer 51(4):727–734

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Xi Jing Hospital, 4th Military Medical University, No. 169 Chang Le Xi Road, Xi’an, 710032, Shaanxi, China

    Lu Yu & Shou Jing Yang

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  1. Lu Yu
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  2. Shou Jing Yang
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Correspondence to Shou Jing Yang.

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Yu, L., Yang, S.J. Primary Osteosarcoma of the Liver: Case Report and Literature Review. Pathol. Oncol. Res. 26, 115–120 (2020). https://doi.org/10.1007/s12253-018-0483-8

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