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Incidence of Contrast-Induced Nephropathy in Patients with Multiple Myeloma Undergoing Contrast-Enhanced Procedures

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Pathology & Oncology Research

Abstract

Multiple myeloma (MM) is a malignant disorder characterized by clonal proliferation of plasma cells. Renal impairment is a common complication. Contrast-induced nephropathy (CIN) is a form of acute renal failure that can occur in the setting of IV contrast administration. It is more commonly seen in patients with pre-existing renal impairment. Patients with MM commonly require contrast enhanced procedures. The literature regarding the safety of IV contrast in this cohort is lacking. A retrospective review was carried out in a university hospital to identify the incidence of CIN in patients with MM and to look for associated risk factors. 94 patients and 165 procedures were included in the analysis. 10% of procedures resulted in CIN. 59% (10/17) of creatinines had normalized within one month of the procedure. The only factor found to be significant for the development of CIN was the timing of the procedure (<18mths verses >18mths post diagnosis of MM; p = 0.045). CIN appears to occur at an increased rate in patients with MM. However this may be an over-estimation given the common occurrence of renal impairment in this cohort and the close temporal relationship which often exists between systemic illness and contrast-enhanced procedures.

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Acknowledgements

Maeve P Crowley designed the study, performed the research and wrote the paper.

Vinitha N Prabhakaran performed the research and wrote the paper.

Oonagh M Gilligan designed the study and wrote the paper.

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Authors and Affiliations

  1. Department of Haematology, Cork University Hospital, Wilton, Cork, Ireland

    Maeve P. Crowley & Oonagh M. Gilligan

  2. Department of Medicine, University College Cork, Cork, Ireland

    Vinitha N. Prabhakaran

Authors
  1. Maeve P. Crowley
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  2. Vinitha N. Prabhakaran
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  3. Oonagh M. Gilligan
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Correspondence to Maeve P. Crowley.

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Conflict of Interest

Maeve P Crowley, Vinitha N Prabhakaran and Oonagh M Gilligan have no conflicts of interest to disclose.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed Consent

Following review at the institutional ethics board, it was deemed unnecessary to obtain informed consent from all individual participants included in the study as no identifying details would be included.

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Crowley, M.P., Prabhakaran, V.N. & Gilligan, O.M. Incidence of Contrast-Induced Nephropathy in Patients with Multiple Myeloma Undergoing Contrast-Enhanced Procedures. Pathol. Oncol. Res. 24, 915–919 (2018). https://doi.org/10.1007/s12253-017-0300-9

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  • DOI: https://doi.org/10.1007/s12253-017-0300-9

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