Skip to main content

Advertisement

SpringerLink
Log in

WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers

  • Letter to the Editor
  • Published:
Pathology & Oncology Research

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M (2008) Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. Cancer Sci 99:843–848

    Article  CAS  PubMed  Google Scholar 

  2. Goto M, Miller RW, Ishikawa Y, Sugano H (1996) Excess of rare cancers in Werner syndrome (adult progeria) (1996) J. Cancer Epidemiol Biomark Prev 5:239–246

    CAS  Google Scholar 

  3. Shimamoto A, Sugimoto M, Furuichi Y (2004) Molecular biology of Werner syndrome 2004. Int J Clin Oncol 9:288–298

    Article  CAS  PubMed  Google Scholar 

  4. Yamagata K, Kato J, Shimamoto A, Goto M, Furuichi Y, Ikeda H (1998) Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A 95:8733–8738

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680

    Article  CAS  PubMed  Google Scholar 

  6. Choi MR, Gwak M, Yoo NJ, Lee SH (2015) Regional bias of Intratumoral genetic heterogeneity of apoptosis-related genes BAX, APAF1, and FLASH in Colon cancers with high microsatellite instability. Dig Dis Sci 60:1674–1679

    Article  CAS  PubMed  Google Scholar 

  7. Kim TM, Jung SH, An CH, Lee SH, Baek IP, Kim MS, Park SW, Rhee JW, Lee SH, Chung YJ (2015) Subclonal genomic architectures of primary and metastatic colorectal cancer based on Intratumoral genetic heterogeneity. Clin Cancer Res 21:4461–4472

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by a grant from National Research Foundation of Korea (2012R1A5A2047939).

Author information

Authors and Affiliations

  1. Departments of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea

    Ju Hwa Lee, Min Sung Kim, Nam Jin Yoo & Sug Hyung Lee

  2. Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Sung Soo Kim

Authors
  1. Ju Hwa Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sung Soo Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Min Sung Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nam Jin Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sug Hyung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sug Hyung Lee.

Ethics declarations

Conflicts of Interest

None to declare.

Additional information

Ju Hwa Lee and Sung Soo Kim contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, J.H., Kim, S.S., Kim, M.S. et al. WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers. Pathol. Oncol. Res. 23, 451–452 (2017). https://doi.org/10.1007/s12253-016-0173-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-016-0173-3

Keywords

Search

Navigation