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May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?

Pathology & Oncology Research volume 23, pages 197–206 (2017)Cite this article

Abstract

Matrix metalloproteinases-2 (MMP-2) and the tissue inhibitor of metalloproteinase-2 (TIMP-2), may presumably have an important role on the invasion and metastatic spread of malignancies attributed to an uncontrolled degradation of the extracellular matrix (ECM). A retrospective chart analysis was carried out to study the expression of MMP-2 and TIMP-2 on the archival samples of oral squamous cell carcinoma (OSCC) (n = 30) and normal mucosa (n = 10) by immunohistochemistry and compared with the clinicopathologic parameters of cases. Both MMP-2 and TIMP-2 expressions showed a positive correlation with the grades, stages and metastatic capacities of tumors (Spearman’s correlation, p < 0.05). Concomitant increase in the expression of TIMP-2 and MMP-2 suggested that the rate of MMP-2/TIMP-2 expression is a better marker for characterization of MMP-2 concentration. High expression and/or activity of MMP-2 were linked with poorer survival in OSCC cases, while TIMPs have been shown to apparently act as either growth-stimulating or suppressor factors for tumors. It was also revealed that MMP-2 and TIMP-2 were secreted by both tumor cells and stromal cells. A new concept, supposing the dynamic, anticancer partnership between the residual genome stabilizer machinery of tumor cells and defensive cells adjacent to tumors, may illuminate the controversial results. In conclusion, the stronger the infiltrative and metastatic capacity of cancers, the higher is the rate of MMP-2/TIMP-2 expression helping the arrival of humoral and cellular anticancer forces.

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Affiliations

  1. Department of Oral Pathology, Chitwan Medical College, Bharatpur, Chitwan, Nepal

    Bijayatha Shrestha

  2. Department of Oral Pathology, Kantipur Dental College, Hospital and Research Center, Kathmandu, Nepal

    Dipshikha Bajracharya

  3. Oral Pathology & Microbiology, Hubli, Karnataka, India

    Aditi Amit Byatnal

  4. Department of Community Medicine, Kasturba Medical College, Manipal University, Manipal, India

    Asha Kamath

  5. Department of Oral Pathology, Manipal College of Dental Sciences, Manipal University, Manipal, 576104, India

    Raghu Radhakrishnan

Authors
  1. Bijayatha Shrestha
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  2. Dipshikha Bajracharya
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  3. Aditi Amit Byatnal
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  4. Asha Kamath
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  5. Raghu Radhakrishnan
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Correspondence to Raghu Radhakrishnan.

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Shrestha, B., Bajracharya, D., Byatnal, A.A. et al. May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?. Pathol. Oncol. Res. 23, 197–206 (2017). https://doi.org/10.1007/s12253-016-0149-3

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  • DOI: https://doi.org/10.1007/s12253-016-0149-3

Keywords

  • Oral squamous cell carcinoma
  • Invasion
  • Matrix metalloproteinases
  • Metastasis
  • MMP-2
  • TIMP-2