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Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

Breast cancer affects every 1 of 3000 pregnant women or in the first post-partum year is referred as Pregnancy Associated Breast Cancer (PABC) in mid 30s. Even-though rare disease, classified under hormone receptor negative status which metastasis quickly to other parts by extra cellular matrix degradation. Hence it is important to find an optimal treatment option for a PABC patient. Also additional care should be taken to choose the drug; in order to avoid fetal malformation and post-partum stage side-effects. The adaptation of target based therapy in the clinical practice may help to substitute the mastectomy treatment. Recent studies suggested that certain altered Post Translational Modifications (PTMs) may be an indicative of breast cancer progression; an attempt is made to consider the over represented PTM as a parameter for gene selection. The public dataset of PABC from GEO were examined to select Differentially Expressed Genes (DEG). The corresponding PTMs for DEG were collected and association between them was found using data mining technique. Usually clustering algorithm has been applied for the study of gene expression with drawback of clustering of gene products based on specified features. But association rule mining method overcome this shortcoming and determines the useful and in depth relationships. From the association, genes were selected to study the interactions and pathways. These studies emphasis that the genes KLF12, FEN1 MUC1 and SP110, can be chosen as target, which control cancer development, without any harm to pregnancy as well as fetal developmental process.

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Acknowledgment

We thank Pranitha Jenardhanan, Manivel Panneerselvam and Kannan Muthu for their valuable suggestions.

Support and Funding

This work was carried out in Centre for Bioinformatics, Pondicherry University under the UGC funded project.

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  1. Centre for Bioinformatics, Pondicherry University, Puducherry, 605014, India

    Raja Rajeswary Thanmalagan, Leimarembi Devi Naorem & Amouda Venkatesan

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  1. Raja Rajeswary Thanmalagan
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  2. Leimarembi Devi Naorem
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Correspondence to Amouda Venkatesan.

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The authors declare that they have no competing interests.

Authors’ Contributions

RT designed the study, performed the analysis and wrote the manuscript. AV, NL contributed to critical review of the manuscript. All authors read and approved the final manuscript.

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Thanmalagan, R.R., Naorem, L.D. & Venkatesan, A. Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. Pathol. Oncol. Res. 23, 537–544 (2017). https://doi.org/10.1007/s12253-016-0133-y

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