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Pathology & Oncology Research

, Volume 23, Issue 2, pp 225–234 | Cite as

Clinical Applications of Next-Generation Sequencing in Cancer Diagnosis

  • Leila Sabour
  • Maryam Sabour
  • Saeid GhorbianEmail author
Review

Abstract

With the advancement and improvement of new sequencing technology, next-generation sequencing (NGS) has been applied increasingly in cancer genomics research fields. More recently, NGS has been adopted in clinical oncology to advance personalized treatment of cancer. NGS is utilized to novel diagnostic and rare cancer mutations, detection of translocations, inversions, insertions and deletions, detection of copy number variants, detect familial cancer mutation carriers, provide the molecular rationale for appropriate targeted, therapeutic and prognostic. NGS holds many advantages, such as the ability to fully sequence all types of mutations for a large number of genes (hundreds to thousands) and the sensitivity, speed in a single test at a relatively low cost compared to be other sequencing modalities. Here we described the technology, methods and applications that can be immediately considered and some of the challenges that lie ahead.

Keywords

NGS Cancer Next-generation sequencing Diagnosis Clinical practice 

Notes

Compliance with Ethical Standards

Conflict of Interest

Maryam Sabour declares that she has no conflict of interest. Leila Sabour declares that she has no conflict of interest. Saeid Ghorbian declares that he has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants performed by any of the authors.

Informed Consent

This article is not involved Informed Consent.

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Copyright information

© Arányi Lajos Foundation 2016

Authors and Affiliations

  1. 1.Department of Molecular Biology, Ahar BranchIslamic Azad UniversityAharIran

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