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Pathology & Oncology Research

, Volume 23, Issue 2, pp 377–383 | Cite as

Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer

  • Madaras Balázs
  • Horváth Zsolt
  • Gráf László
  • Gálffy Gabriella
  • Tamási Lilla
  • Ostoros Gyula
  • Döme Balázs
  • Mórocz Éva
  • Bártfai Zoltán
  • Prohászka Zoltán
  • Kocsis JuditEmail author
Original Article

Abstract

The 70 kDa heat shock protein (Hsp70) is a highly conservative molecular chaperone, that has important role in cell integrity. Recently considerable amount of data are accumulating on the potential role of Hsp70 in carcinogenesis and tumor progression. Most papers are focusing on intracellular or membrane bound protein, however very limited data exist on serum Hsp70, that can also induce innate and adaptive immune response. Previously we have published data on the correlation between coloretal cancer progression and serum Hsp70 concentration. The objective of this study was to compare the serum Hsp70 level in patients with small cell lung cancer (SCLC n = 70) and age matched healthy controlls (n = 121) and correlate Hsp70 level with other known serum biomarkers (LDH and NSE) of the disease. We found that the serum level of Hsp70 was significantly higher in SCLC patients compared to control subjects (mean value 6.91 vs 2.47 ng/ml, p = 0.001). The highest Hsp70 concentration was measured in stage IV advanced SCLC (Stage IV versus Stage I-III disease: 9.91 vs 4.38 ng/ml, p = 0.003). The serum Hsp70 level correlated with serum LDH (r = 0.426, p < 0,001) and NSE level (r = 0.455, p < 0,001). We found that high serum Hsp70 level predicted unfavorable survival, risk of death within 1 year was more than 3 times higher in patients with high baseline Hsp70 level (HR:3.509, CI: 1.066–11.562; p = 0.039). Our observations indicate that serum Hsp70 could be a valuable diagnostic and prognostic marker in small cell lung cancer.

Keywords

Small cell lung cancer Hsp70 Biomarker Prognostic marker Target 

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Copyright information

© Arányi Lajos Foundation 2016

Authors and Affiliations

  • Madaras Balázs
    • 1
  • Horváth Zsolt
    • 2
  • Gráf László
    • 3
  • Gálffy Gabriella
    • 4
  • Tamási Lilla
    • 4
  • Ostoros Gyula
    • 5
  • Döme Balázs
    • 5
  • Mórocz Éva
    • 6
  • Bártfai Zoltán
    • 7
  • Prohászka Zoltán
    • 3
  • Kocsis Judit
    • 2
    • 3
    Email author
  1. 1.National Institute of OncologyBudapestHungary
  2. 2.Institute of OncologyUniversity of DebrecenDebrecenHungary
  3. 3.3rd Department of Internal MedicineSemmelweis University BudapestBudapestHungary
  4. 4.Department of PulmonologySemmelweis University BudapestBudapestHungary
  5. 5.Department of Tumor BiologyNational Koranyi Institute of PulmonologyBudapestHungary
  6. 6.Pulmonology HospitalTörökbálintHungary
  7. 7.Department of PulmonologyElizabeth Teaching Hospital and Rehabilitation Institute SopronSopronHungary

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