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Pathology & Oncology Research

, Volume 23, Issue 2, pp 265–270 | Cite as

Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer

  • Jian Chen
  • Lijuan Hu
  • Junjun Wang
  • Fan Zhang
  • Jie Chen
  • Gang Xu
  • Yumin WangEmail author
  • Qinshi PanEmail author
Original Article

Abstract

We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression TUBA4B in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.

Keywords

Non-small cell lung cancer lncRNAs TUBA4B Prognosis 

Notes

Acknowledgments

Funding/Grant Support/Acknowledgments: This study was financially supported by the National Natural Science Foundation of China (8140736), the Zhejiang Provincial Natural Science Foundation (LQ16H160020), and the Wenzhou Municipal Science and Technology Bureau, China (Y20150097).

Compliance with Ethical Standards

Conflict of Interest Statement

These conflicts did not interfere with the conduct of this study. All other authors have no other conflict of interest to declare.

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Copyright information

© Arányi Lajos Foundation 2016

Authors and Affiliations

  1. 1.Department of Laboratory Medicinethe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China
  2. 2.Department of Intensive Care Unitthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouPeople’s Republic of China

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