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Frameshift Mutations of CAB39L, an Activator of LKB1 Tumor Suppressor, in Gastric and Colorectal Cancers

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Pathology & Oncology Research

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References

  1. Alessi DR, Sakamoto K, Bayascas JR (2006) LKB1-dependent signaling pathways. Transcription 4:29–33

    Google Scholar 

  2. Hemminki A, Tomlinson I, Markie D, Järvinen H, Sistonen P, Björkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la Chapelle A, Aaltonen LA (1997) Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 15:87–90

    Article  CAS  PubMed  Google Scholar 

  3. Sanchez-Cespedes M (2007) A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 26:7825–7832

    Article  CAS  PubMed  Google Scholar 

  4. Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM (2013) Structural insights into the activation of MST3 by MO25. Biochem Biophys Res Commun 431:604–609

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Ling P, Lu TJ, Yuan CJ, Lai MD (2008) Biosignaling of mammalian Ste20-related kinases. Cell Signal 20:1237–1247

    Article  CAS  PubMed  Google Scholar 

  6. Imai K (2008) Yamamoto H (2008) carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680

    Article  CAS  PubMed  Google Scholar 

  7. Yoo NJ, Kim HR, Kim YR, An CH (2012) Lee SH (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60:943–952

    Article  PubMed  Google Scholar 

  8. Je EM, Kim MR, Min KO, Yoo NJ, Lee SH (2012) Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors. Int J Cancer 131:E1044–E1047

    Article  CAS  PubMed  Google Scholar 

  9. Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz Jr LA, Kinzler KW (2013) Cancer genome landscapes. Science 339:1546–1558

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12:323–334

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by a grant from National Research Foundation of Korea (2012R1A5A2047939).

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Correspondence to Sug Hyung Lee.

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Mi Ryoung Choi and Chang Hyeok An contributed equally to this work.

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Choi, M.R., An, C.H., Yoo, N.J. et al. Frameshift Mutations of CAB39L, an Activator of LKB1 Tumor Suppressor, in Gastric and Colorectal Cancers. Pathol. Oncol. Res. 22, 225–226 (2016). https://doi.org/10.1007/s12253-015-9973-0

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