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Clinicopathologic Comparison of Urothelial Bladder Carcinoma in Young and Elder Patients

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Pathology & Oncology Research

Abstract

Bladder cancer (BC) is a common aggressive malignancy and Urothelial bladder cancer (UBC) consists of the majority of BC. There is uncertainty regarding the clinicopathologic characteristics of UBCs in younger patients. To investigate the clinicopathologic features of young patients with UBCs. A total of 2825 pathological records of UBC patients, including 42 young patients (≤ 30 years old) and 2783 elder patients (> 30 years old), were retrospectively studied. The stage distribution classified was statistically significant (Χ 2 = 12.25, P = 0.02) between young and old patients; superficial tumors was far more in young patients than in old patients. More young patients tended to be low- and moderate-grade UBCs (Χ 2 = 6.75, P = 0.009). Young patients with superficial UBCs also showed lower recurrence rate, compared to elder patients (Χ 2 = 5.77, P = 0.02). For 5-year survival rate, young patients (93.8 %) showed better than elder patients (85.1 %) (Χ 2 = 4.01, P = 0.045). Patients younger than 30 years old with UBCs had low-grade and low-stage tumors and exhibited better prognosis than elder patients.

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Acknowledgments

This study was partially supported by a grant from Des Moines University to Yujiang Fang.

Conflict of Interest

The authors declare that they have no conflict of interest relating to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao, 266000, China

    Qing-hai Wang

  2. Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China

    Zhi-Gang Ji, Han-zhong Li, Hua Fan, Zhi-gang Chen & Bing-bing Shi

  3. Department of Microbiology and Immunology, Des Moines University, College of Osteopathic Medicine, Des Moines, IA, 50312, USA

    Yujiang Fang

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  1. Qing-hai Wang
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  2. Zhi-Gang Ji
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  3. Han-zhong Li
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  4. Hua Fan
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  5. Zhi-gang Chen
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  6. Bing-bing Shi
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  7. Yujiang Fang
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Correspondence to Bing-bing Shi or Yujiang Fang.

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Wang, Qh., Ji, ZG., Li, Hz. et al. Clinicopathologic Comparison of Urothelial Bladder Carcinoma in Young and Elder Patients. Pathol. Oncol. Res. 22, 67–70 (2016). https://doi.org/10.1007/s12253-015-9968-x

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  • DOI: https://doi.org/10.1007/s12253-015-9968-x

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