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The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

Gallbladder cancers (GBCs) are highly malignant gastrointestinal cancers. The biological makers for the prognosis and targeting therapy of GBCs have not been established. The protein expression of Notch 1 and Notch 3 in 46 squamous cell/adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (AC) was measured using immunohistochemistry. Positive Notch 1 and Notch 3 expression in both SC/ASC and AC was significantly associated with large tumor size, invasion, metastasis, and low surgical curability (P < 0.05 or P < 0.01). Univariate Kaplan-Meier analysis showed that positive Notch 1 and Notch 3 expression was significantly associated with mean survival of SC/ASC and AC patients (P < 0.01 or P < 0.001). Multivariate Cox regression analysis showed that positive Notch 1 and Notch 3 expression, as well as low differentiation, large tumor size, high TNM stage, invasion, lymph node metastasis, and surgical curability are independent poor-prognostic factors in both SC/ASC and AC patients. Positive Notch 1 and Notch 3 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in both SC/ASC and AC patients.

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Authors and Affiliations

  1. Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China

    Luyao Liu, Zhu-lin Yang, Chunwei Wang, Xiongying Miao & Zhiyu Liu

  2. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China

    Daiqiang Li

  3. Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People’s Republic of China

    Qiong Zou

  4. Department of Pathology, Basic School of Medicine, Central South University, Changsha, Hunan, 410078, People’s Republic of China

    Jinghe Li

  5. Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People’s Hospital, Changsha, Hunan, 410007, People’s Republic of China

    Lufeng Liang

  6. Department of Pathology, Loudi Central Hospital, Loudi, Hunan, 417011, People’s Republic of China

    Guixiang Zeng

  7. Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan, 410013, People’s Republic of China

    Senlin Chen

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  1. Luyao Liu
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  2. Zhu-lin Yang
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  3. Chunwei Wang
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  4. Xiongying Miao
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  5. Zhiyu Liu
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  7. Qiong Zou
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  8. Jinghe Li
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  9. Lufeng Liang
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  10. Guixiang Zeng
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  11. Senlin Chen
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Correspondence to Zhu-lin Yang.

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Liu, L., Yang, Zl., Wang, C. et al. The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance. Pathol. Oncol. Res. 22, 483–492 (2016). https://doi.org/10.1007/s12253-015-0019-4

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  • DOI: https://doi.org/10.1007/s12253-015-0019-4

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