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Expression of Secreted Frizzled-Related Protein 1 and 3, T-cell Factor 1 and Lymphoid Enhancer Factor 1 in Clear Cell Renal Cell Carcinoma

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Pathology & Oncology Research

Abstract

Frequency and mortality of renal cell carcinoma (RCC) are increasing for decades. However, the molecular background of RCC tumorigenesis is still poorly understood. In current study we investigated the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). Thirty-six pairs of paraffin-embedded clear cRCC and adjacent nontumoral tissues samples using immunohistochemistry (IHC) were analyzed and compared with corresponding clinicopathological parameters. Immunohistochemistry indicated statistically significant decreased SFRP3 expression in tumor tissues but no consistency in SFRP1 expression in analyzed normal and tumor tissue. The TCF1 expression level was significantly weaker in normal tissue compared to tumor samples while LEF1 protein levels were significantly weaker in tumor tissue. To our knowledge, this is the first report on analysis of the expression of transcription factors TCF1 and LEF1 in clear cell renal cell carcinoma and their comparison with Wnt signal pathway antagonists belonging to SFRP family.

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I hereby certify absence of actual or potential conflict of interest in relation to this article.

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Authors and Affiliations

  1. Department of Biology, School of Medicine, University of Zagreb, Šalata 3, 10000, Zagreb, Croatia

    Tamara Nikuševa-Martić, Ljiljana Šerman & Nives Pećina-Šlaus

  2. Department of Internal Medicine, “Merkur” University Hospital, Zagreb, Croatia

    Martina Zeljko & Hrvojka Marija Zeljko

  3. Department of Urology, “Merkur” University Hospital, Zagreb, Croatia

    Željko Vidas

  4. Department of Clinical Pathology and Cytology, “Merkur” University Hospital, Zagreb, Croatia

    Slavko Gašparov

  5. Department of Physics and Biophysics, School of Medicine, University of Zagreb, Zagreb, Croatia

    Marin Kosović

Authors
  1. Tamara Nikuševa-Martić
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  2. Ljiljana Šerman
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  3. Martina Zeljko
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  4. Željko Vidas
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  5. Slavko Gašparov
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  6. Hrvojka Marija Zeljko
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  7. Marin Kosović
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  8. Nives Pećina-Šlaus
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Correspondence to Tamara Nikuševa-Martić.

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Nikuševa-Martić, T., Šerman, L., Zeljko, M. et al. Expression of Secreted Frizzled-Related Protein 1 and 3, T-cell Factor 1 and Lymphoid Enhancer Factor 1 in Clear Cell Renal Cell Carcinoma. Pathol. Oncol. Res. 19, 545–551 (2013). https://doi.org/10.1007/s12253-013-9615-3

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  • DOI: https://doi.org/10.1007/s12253-013-9615-3

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