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The Significance of non Correlation Between Interleukin-8 Serum Levels with Bone Marrow Microvascular Density in Patients with Myeloma Multiple

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Pathology & Oncology Research

Abstract

In multiple myeloma (MM), angiogenesis plays a substantial role in disease progression. Interleukin-8 (IL-8), a pro-inflammatory chemokine with potent pro-angiogenic properties, has been implicated in the pathophysiology of MM. The aim of the study is to measure serum levels of IL-8 in MM patients and to correlate them with markers of angiogenesis, such as circulating levels of platelet derived growth factor-AB (PDGF-AB) and angiogenin (Ang), and bone marrow microvascular density (MVD). Fifty-three newly diagnosed MM patients, 23 of them, who reached plateau phase after effective treatment and 20 healthy controls, were studied. Serum levels of PDGF-AB, Ang and IL-8 were measured by ELISA, whereas bone marrow MVD was estimated by immunohistochemical staining of vessels with anti-CD31. All measured parameters were higher in MM patients compared to controls and in increased disease stages. They all also significantly decreased in plateau phase. IL-8 correlated positively with Ang and PDGF-AB, but not with MVD. The circulating levels of IL-8, PDGF-AB and Ang are elevated in patients with MM. The lack of correlation between IL-8 with MVD suggests that its levels represent the inflammatory element of MM disease and the participation in angiogenesis process is rather complex with multifactorial mechanisms.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Hematology Department, Venizelion Hospital of Heraklion, Knossou Avenue, zip code 71409, Heraklion, Greece

    Constantina A. Pappa, Anna Boula, Aikaterini Sfiridaki & Fotios E. Psarakis

  2. Hematology Department, University Hospital of Heraklion, Stavrakia, zip code 71110, Heraklion, Greece

    George Tsirakis & Michael G. Alexandrakis

  3. Pathology Department, University Hospital of Heraklion, Stavrakia, zip code 71110, Heraklion, Greece

    Efstathios N. Stathopoulos

Authors
  1. Constantina A. Pappa
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  2. George Tsirakis
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  3. Anna Boula
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  4. Aikaterini Sfiridaki
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  5. Fotios E. Psarakis
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  6. Michael G. Alexandrakis
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  7. Efstathios N. Stathopoulos
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Correspondence to Michael G. Alexandrakis.

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Pappa, C.A., Tsirakis, G., Boula, A. et al. The Significance of non Correlation Between Interleukin-8 Serum Levels with Bone Marrow Microvascular Density in Patients with Myeloma Multiple. Pathol. Oncol. Res. 19, 539–543 (2013). https://doi.org/10.1007/s12253-013-9614-4

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  • DOI: https://doi.org/10.1007/s12253-013-9614-4

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