Abstract
To investigate the clinical efficacy of intra-arterial chemotherapy by subcutaneous implantable delivery system (SIDS) in the treatment of distal femur neoplasm. From March 2002 to December 2009, 51 patients were treated with SIDS intra-femoral artery chemotherapy, followed by customized prosthetic reconstruction, including 45 patients of osteosarcoma and 6 malignant fibrous histiocytoma in distal femur. The average follow-up period was 64 months (ranging between 24 and 116 months) to track on the efficacy of chemotherapy, which shows that 96.1 % of patients got pain relief, 70.6 % of patients had significant radiological change, and 82.4 % of paitents with medium to severe pathological variation responded to the chemotherapy. Local recurrence happened in 4 cases, 3 cases are alive with disease, 4 cases died because of pulmonary metastases and other 40 patients are free of local recurrence or distant metastasis. SIDS intra-femur artery chemotherapy can improve clinical outcome of DFN, and provide effective method for treatment of DFN when combined with customized prosthetic reconstruction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wilkins RM, Cullen JW, Camozzi AB et al (2005) Improved survival in primary nonmetastatic pediatric osteosarcoma of the extremity. Clin Orthop Relat Res 438:128–136
Zhang HJ, Yang JJ, Lu JP et al (2009) Use of intra-arterial chemotherapy and embolization before limb salvage surgery for osteosarcoma of the lower extremity. Cardiovasc Intervent Radiol 32(4):672–678
Abe S, Tateishi A, Ogawa K et al (2001) Long-term local intensive preoperative chemotherapy and joint-preserving conservative surgery for osteosarcoma around the knee. Orthopedics 24(7):671–676
Wilkins RM, Cullen JW, Odom L et al (2003) Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. Ann Surg Oncol 10(5):498–507
Cullen JW, Jamroz BA, Stevens SL et al (2005) The value of serial arteriography in osteosarcoma: delivery of chemotherapy, determination of therapy duration, and prediction of necrosis. J Vasc Interv Radiol 16(8):1107–1119
Dingfeng L, Qiu C, Haitao F (2005) Development of adjustable prosthesis and its preliminary application in limb salvage treatment of osteosarcoma in the lower segment of femur. Chin J Reparative Reconstr Surg 19(7):534–536
Li DF, Cui Q, Wang Q, Su H et al (2006) Application of I125 brachytherapy combined artificial joint prosthesis in malignant osteo- and soft-tissue sarcoma. Cancer Biother Radiopharm 21(2):167–172
Cui Q, Li DF, Liu C et al (2011) Two case-reports of the limb salvage treatment of osteosarcoma consolidated with obvious pathological fractures. Pathol Oncol Res 17:973–979
Wu CC, Pritsch T, Shehadeh A et al (2008) The anterior popliteal approach for popliteal exploration, distal femoral resection, and endoprosthetic reconstruction. J Arthroplasty 23(2):254–262
Hugate RR, Wilkins RM, Kelly CM et al (2008) Intraarterial chemotherapy for extremity osteosarcoma and MFH in adults. Clin Orthop Relat Res 466(6):1292–1301
Gelderblom H, Jinks RC, Sydes M et al (2011) Survival after recurrent osteosarcoma: data from 3 European Osteosarcoma Intergroup (EOI) randomized controlled trials. Eur J Cancer 47(6):895–902
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Liu, C., Cui, Q., Shu, C. et al. Comprehensive Treatment Based on Intra-arterial Chemotherapy for Distal Femur Neoplasms. Pathol. Oncol. Res. 19, 489–493 (2013). https://doi.org/10.1007/s12253-013-9606-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12253-013-9606-4