Abstract
Oncogenic HPVs have been found frequently integrated into human genome of invasive cancers and chromosomal localization has been extensively investigated in cervical carcinoma. Few studies have analyzed the HPV integration loci in other genital cancers. We have characterized the integration sites of HPV16 in invasive penile carcinoma by means of Alu-HPV-based PCR. Nucleotide sequence analysis of viral–human DNA junctions showed that HPV integration occurred in one case within the chromosome 8q21.3 region, in which the FAM92A1 gene is mapped, and in the second case inside the chromosome 16p13.3, within the intronic region of TRAP1 gene. These results confirm previous observations, summarized in a systematic review of the literature, on the HPV integration events in gene loci relevant to cancer pathogenesis.
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Abbreviations
- HPV:
-
Human Papillomavirus
- PC:
-
Penile Cancer
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Acknowledgments
We thank Paola Cetrangolo for technical assistance in sample analysis. This work was supported by grants from Ministero della Salute (Programma Integrato Oncologia RO4/2007 and Ricerca Corrente 2011) and from ICSC-World Laboratory (project MCD-2/7).
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Annunziata, C., Buonaguro, L., Buonaguro, F.M. et al. Characterization of the Human Papillomavirus (HPV) Integration Sites into Genital Cancers. Pathol. Oncol. Res. 18, 803–808 (2012). https://doi.org/10.1007/s12253-012-9507-y
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DOI: https://doi.org/10.1007/s12253-012-9507-y