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The Significance of Preoperative Chemotherapy in Evaluation of Recurrent Soft Tissue Liposarcoma Necrosis

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Pathology & Oncology Research

Abstract

To investigate the effect of preoperative induction chemotherapy on treatment of recurrent liposarcoma. 21 patients with recurrent liposarcoma received the treatment of preoperative intra-arterial chemotherapy and surgical resection. Intra-arterial chemotherapy was given by subcutaneous implantable drug delivery system with infusion of cisplatin and doxorubicin followed by caffeine. After treatment, patients were followed up for 39 months. The liposarcoma changes in CT imaging were observed in 18 cases and there were 15 cases with medium or severe pathological changes caused by chemotherapy. At the end of the postoperative follow-up of 39 months, liposarcoma reoccurred locally in 2 cases; pulmonary metastasis occurred in 1 case and death in 3 cases. Preoperative intra-arterial chemotherapy is effective for highly malignant tumors such as recurrent liposarcoma and the judgment of prognosis is based on the postoperative pathological changes of such tumor.

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Authors and Affiliations

  1. Department of Bone Tumor, 307th Hospital of PLA, Beijing, 100071, People’s Republic of China

    Qiu Cui, Dingfeng Li, Shubin Liu, Lei Wang, Ping Zhang, Ju Zhou, Cheng Liu & Weihao Jiang

  2. Biomedical Engineering Center, Beijing University of Technology, Beijing, 100022, China

    Jing Zhang, Xiaohong Wang & Yanjun Zeng

Authors
  1. Qiu Cui
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  2. Dingfeng Li
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  3. Jing Zhang
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  4. Xiaohong Wang
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  5. Shubin Liu
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  6. Lei Wang
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  7. Ping Zhang
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  8. Ju Zhou
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  9. Cheng Liu
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  10. Weihao Jiang
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  11. Yanjun Zeng
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Corresponding authors

Correspondence to Dingfeng Li or Yanjun Zeng.

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Cui, Q., Li, D., Zhang, J. et al. The Significance of Preoperative Chemotherapy in Evaluation of Recurrent Soft Tissue Liposarcoma Necrosis. Pathol. Oncol. Res. 18, 629–633 (2012). https://doi.org/10.1007/s12253-011-9487-3

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  • DOI: https://doi.org/10.1007/s12253-011-9487-3

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