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Indeterminate Cell Histiocytosis in a Pediatric Patient: Successful Treatment with Thalidomide

  • Case Report
  • Published:
Pathology & Oncology Research

Abstract

The 15-year-old male patient presented several 2–6 mm large livid reddish-yellowish, shiny, compact papules on the head, trunk and extremities, which had developed within the last 4 months. Histology showed normal epidermis with dense dermal infiltrate of histiocytes accompanied by few eosinophils, Touton or foamy giant cells. The histiocytes were S100 positive, CD1a negative and did not contain Birbeck granules ultrastructurally. Chest X ray, EEG, skull MRI did not show pathology. Opthalmology, neurology, oto-rhino-laryngology did not reveal alterations. Based upon the clinical symptoms and the histopathology, the diagnosis of indeterminate cell histiocytosis was confirmed. Cryotherapy and cauterization did not stop the progression of the disease, however, under thalidomide treatment no new symptoms developed and the lesions healed with pigmentation.

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Abbreviations

ICH:

Indetreminate cell histiocytosis

MRI:

Magnetic Resonance Imaging

EEG:

Electroencephalogram

CD1a:

Cluster of Differentiation 1a

CD4:

Cluster of Differentiation 4

CD68:

Cluster of Differentiation 68

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Authors and Affiliations

  1. Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária utca 41, 1085, Budapest, Hungary

    Béla Tóth, Mária Katona, Judit Hársing & Sarolta Kárpáti

  2. I. Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

    Ágota Szepesi

  3. Hungarian Academy of Sciences, Molecular Medicine Research Group, Budapest, Hungary

    Sarolta Kárpáti

Authors
  1. Béla Tóth
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  2. Mária Katona
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  3. Judit Hársing
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  4. Ágota Szepesi
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  5. Sarolta Kárpáti
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Correspondence to Béla Tóth.

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Tóth, B., Katona, M., Hársing, J. et al. Indeterminate Cell Histiocytosis in a Pediatric Patient: Successful Treatment with Thalidomide. Pathol. Oncol. Res. 18, 535–538 (2012). https://doi.org/10.1007/s12253-011-9405-8

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  • DOI: https://doi.org/10.1007/s12253-011-9405-8

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