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Efficacy of Romiplostim in the Treatment of Chemotherapy Induced Thrombocytopenia (CIT) in a Patient with Mantle Cell Lymphoma

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Pathology & Oncology Research

Abstract

Chemotherapy induced thrombopenia (CIT) is difficult to treat, as previous treatment options, including recombinant human thrombopoietin proved to be of limited efficacy. Here we report a case of a mantle cell lymphoma patient treated with intensive chemotherapy, who belongs to Yehova’s witnesses and therefore did not accept platelet transfusions. At the time of severe thrombocytopenia (zero thrombocytes/ per mikroliter) and gastrointestinal bleeding, on day 13 following the start of hyperCVAD B chemotherapy, romiplostim treatment was given resulting in quick normalisation of the platelet count followed by thrombocytosis. Based on our observation in further studies modification of the dose and timing of romiplostim injection in CIT should be considered.

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Authors and Affiliations

  1. First Department of Medicine, Faculty of Medicine, Semmelweis University, Korányi Sándor utca 2/A, Budapest, 1083, Hungary

    Judit Demeter, Ildiko Istenes, Anikó Fodor, Melinda Paksi & Zsolt G. Nagy

  2. Department of Haematology and Oncology, St. Borbála Hospital, Tatabánya, Hungary

    Peter Dombi & Erika Valasinyószki

  3. First Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

    Judit Csomor & András Matolcsy

Authors
  1. Judit Demeter
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  2. Ildiko Istenes
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  3. Anikó Fodor
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  4. Melinda Paksi
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  5. Peter Dombi
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  6. Erika Valasinyószki
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  7. Judit Csomor
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  8. András Matolcsy
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  9. Zsolt G. Nagy
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Correspondence to Judit Demeter.

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Demeter, J., Istenes, I., Fodor, A. et al. Efficacy of Romiplostim in the Treatment of Chemotherapy Induced Thrombocytopenia (CIT) in a Patient with Mantle Cell Lymphoma. Pathol. Oncol. Res. 17, 141–143 (2011). https://doi.org/10.1007/s12253-010-9276-4

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  • DOI: https://doi.org/10.1007/s12253-010-9276-4

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