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The Role of the Bone Marrow Derived Mesenchymal Stem Cells in Colonic Epithelial Regeneration

  • Published:
Pathology & Oncology Research

Abstract

Bone marrow derived mesenchymal stem cells (BM-MSCs) take part in the colonic mucosal regeneration. They are multipotent cells, which can be identified with both negative (i.e. CD13, CD 14, CD45, c-Kit, major histocompatibility complex /MHC class I and II) and positive (i.e. CD54 (ICAM1), CD133, CD146 (MCAM), CD166, Flk-1, Sca-1, Thy-1, stage-specific antigen I /SSEA-I and Musashi-1, HLA class I) markers. These cells can repopulate the gastrointestinal mucosa as they may differentiate into stromal- (i.e. myofi-broblast) or epithelial-like (Paneth-, epithel-, goblet or enteroendocrin) cells without proliferation. During the mesenchymal to epithelial transition (MET) stem cells enter the epithelial layer and take up epithelial cell-like properties. Rarely BM-MSCs may retain their stem cell characteristics and are capable of producing progeny. The isolated lymphoid aggregates may serve as a platform from where BM-MSCs migrate to the nearby crypts as mediated by several chemoattractant proteins, which are expressed in injured tissue. The number of BM-MSCs is influenced by the degree of inflammation. In this review we summarize the current information about the role of BM-MSCs in the repair progress of injured colonic epithelium and their potential clinical applications.

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Authors and Affiliations

  1. 2nd Department of Internal Medicine, Cell Analysis Laboratory, Semmelweis University, Szentkiralyi Street 46, 1088, Budapest, Hungary

    Gábor Valcz, Ferenc Sipos, Katalin Leiszter, Kinga Tóth, Györgyi Műzes, Béla Molnár & Zsolt Tulassay

  2. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

    Tibor Krenács, Zsófia Balogh & Annamária Csizmadia

  3. Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest, Hungary

    Béla Molnár & Zsolt Tulassay

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  1. Gábor Valcz
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  2. Tibor Krenács
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Correspondence to Gábor Valcz.

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Valcz, G., Krenács, T., Sipos, F. et al. The Role of the Bone Marrow Derived Mesenchymal Stem Cells in Colonic Epithelial Regeneration. Pathol. Oncol. Res. 17, 11–16 (2011). https://doi.org/10.1007/s12253-010-9262-x

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  • DOI: https://doi.org/10.1007/s12253-010-9262-x

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