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SDF1-3'A Gene Polymorphism is Associated with Laryngeal Cancer

  • Published:
Pathology & Oncology Research

Abstract

The SDF1-3’ G801A (rs 1801157) polymorphism is associated with increased risk of various types of cancers, including those of the neck and head. Using PCR-RFLPs, we investigated the distribution of SDF1-3′ G801A genotypes in patients with laryngeal cancer (n = 118) and controls (n = 250) in Poland. We found that patients with SDF1-3’ A/A and G/A genotypes exhibit a 1.863-fold increased risk of laryngeal cancer (95% CI = 1.177–2.949, p = 0.0086). However, there was no significant increase in risk for the homozygous SDF1-3’ A/A genotype OR = 3.235 (95% CI = 0.5330−19.633, p = 0.3329). We also did not observe a significant association between tumor characteristics and prevalence of alleles or genotypes for the SDF1-3′ G801A polymorphism. Our findings suggest that the SDF1-3'A variant may be associated with an increased risk of laryngeal cancer.

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Acknowledgements

Supported by a grant No 502-01-01124182-07474 Poznań University of Medical Sciences.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St., 60-781, Poznań, Poland

    Łukasz Kruszyna, Margarita Lianeri & Paweł P. Jagodziński

  2. Department of Environmental Mutagenesis, Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland

    Małgorzata Rydzanicz & Krzysztof Szyfter

  3. Department of Otolaryngology and Laryngeal Oncology, Poznań University of Medical Sciences, Poznań, Poland

    Krzysztof Szyfter

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  1. Łukasz Kruszyna
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  2. Margarita Lianeri
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  3. Małgorzata Rydzanicz
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  4. Krzysztof Szyfter
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  5. Paweł P. Jagodziński
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Correspondence to Paweł P. Jagodziński.

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Kruszyna, Ł., Lianeri, M., Rydzanicz, M. et al. SDF1-3'A Gene Polymorphism is Associated with Laryngeal Cancer. Pathol. Oncol. Res. 16, 223–227 (2010). https://doi.org/10.1007/s12253-009-9214-5

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  • DOI: https://doi.org/10.1007/s12253-009-9214-5

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