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Minimally Invasive Therapy of Cervical Intraepithelial Neoplasia for Fertility Preservation

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Pathology & Oncology Research

Abstract

The aim of this study was to determine the extension of cervical intraepithelial neoplasia grade III (CIN III) into endocervical canal and depth of endocervical crypts involvement by CIN with the regard to patients’ age and parity. Correlation between the area of CIN involvement and the extension into endocervical canal was estimated. A total of 218 cervical cone specimens with histologically proven CIN III were included in this study. Extension of CIN into the endocervical canal, depth of involved crypts and ectocervical area affected by CIN were histologically analyzed. The average endocervical crypt involvement was at 1.2 mm of depth. The excision of >4 mm (1.2 mm × 3S.D.) in depth removes >99% of CIN. With the cone length of 15 mm (nulliparous patients) and 18 mm (multiparous patients), no endocervical cone margins were affected with CIN. Since the cone length is the most important determining factor for fertility preservation, the measurement of cervical cone could be essential for future pregnancies.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, General Hospital Gospić, Gospić, Croatia

    Darko Milinovic

  2. Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia

    Drzislav Kalafatic, Helena Lovric Grsic & Slavko Oreskovic

  3. Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia

    Damir Babic

  4. Department of Oncology, University Hospital for Tumors, Zagreb, Croatia

    Lidija Beketic Oreskovic

Authors
  1. Darko Milinovic
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  2. Drzislav Kalafatic
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  3. Damir Babic
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  4. Lidija Beketic Oreskovic
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  5. Helena Lovric Grsic
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  6. Slavko Oreskovic
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Correspondence to Drzislav Kalafatic.

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Milinovic, D., Kalafatic, D., Babic, D. et al. Minimally Invasive Therapy of Cervical Intraepithelial Neoplasia for Fertility Preservation. Pathol. Oncol. Res. 15, 521–525 (2009). https://doi.org/10.1007/s12253-009-9148-y

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  • DOI: https://doi.org/10.1007/s12253-009-9148-y

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