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Breast Carcinoma Metastasis in Recurrent Myxoid Liposarcoma

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  • Published:
Pathology & Oncology Research

Abstract

Tumor to tumor metastasis is a rare, but well recognized entity, most commonly involving a carcinoma metastasis to a benign or low grade mesenchymal tumor. A case of breast carcinoma metastasis in a recurrent myxoid liposarcoma is presented in this study. A 52-year-old female patient with a history of breast carcinoma (70% invasive lobular carcinoma and 30% invasive ductal carcinoma) presented with a mass in the right lumbar region. The excised mass was diagnosed as myxoid liposarcoma. The tumor recurred twice and was reexcised. Microscopic examination of the second recurrence revealed multiple foci of breast carcinoma metastases in myxoid liposarcoma. Immunohistochemical study showed staining for CK19, GCDFP-15, estrogen and progesterone in metastases. Both breast carcinoma metastasis and myxoid liposarcoma were immunoreactive for E-cadherin and beta-catenin. To our knowledge, this is the first reported case of breast carcinoma metastasis in myxoid liposarcoma, and the first occurrence of metastasis in a liposarcoma.

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References

  1. Campbell LV, Gilbert E, Chamberlain CR et al (1968) Metastases of cancer to cancer. Cancer 22:635–643

    Article  PubMed  Google Scholar 

  2. Gore I, Barr R (1957) Metastasis of cancer to cancer. Arch Pathol 66:293–298

    Google Scholar 

  3. Grignon DJ, Ro JY, Ayala AG (1989) Malignant melanoma with metastasis to adenocarcinoma of the prostate. Cancer 63:196–198

    Article  CAS  PubMed  Google Scholar 

  4. Cohn ML, Elliot DD, El-Naggar AK (2004) Metastatic acinic cell carcinoma in neurofibroma mistaken for carcinosarcoma. Head Neck 27:76–80

    Article  Google Scholar 

  5. Perry LJ, Lewis JC, Ball RY (1996) Adenocarcinoma of the breast metastatic to benign ovarian fibroma. Gynecol Oncol 62:408–410

    Article  CAS  PubMed  Google Scholar 

  6. Uner A, Tiras MB, Kilic D et al (2003) Uterine lipoleiomyoma containing metastatic breast carcinoma: a case with two unusual pathologies. Eur J Obstet Gynecol Reprod Biol 106:76–78

    Article  PubMed  Google Scholar 

  7. Fadare O, Parkash V, Fiedler PN, Mayerson AB, Asiyanbola B (2005) Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma. Pathol Int 55:574–579

    Article  PubMed  Google Scholar 

  8. Bhargava P, McGrail KM, Manz HJ (1999) Lung carcinoma presenting as metastasis to intracranial meningioma: case report and review of the literature. Am J Clin Oncol 22:199–202

    Article  CAS  PubMed  Google Scholar 

  9. Wong A, Koszyca B, Blumbergs PC et al (1999) Malignant melanoma metastatic to meningioma. Pathology 31:162–165

    Article  CAS  PubMed  Google Scholar 

  10. Hamazaki S, Nakashima H, Matsumoto K et al (2001) Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel-Lindau disease. Pathol Int 51:948–953

    Article  CAS  PubMed  Google Scholar 

  11. Baloch ZW, LiVolsi VA (1999) Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med 123:703–706

    CAS  PubMed  Google Scholar 

  12. Petraki C, Vaslamatzis M, Argyrakos T et al (2003) Tumor to tumor metastasis: report of two cases and a review of the literature. Int Surg Pathol 11:127–135

    Article  Google Scholar 

  13. Woodhouse EC, Chuaqui RF, Liotta LA (1997) General mechanisms of metastasis. Cancer 80:1529–1537

    Article  CAS  PubMed  Google Scholar 

  14. Thompson EW, Newgreen DF (2005) Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition. Cancer Res 65:5991–5995

    Article  CAS  PubMed  Google Scholar 

  15. Sugarbaker EV (1979) Some characteristics of metastasis in man. Am J Pathol 97:623–632

    CAS  PubMed  Google Scholar 

  16. Chambers PW, Davis RL, Blanding JD (1980) Metastases to primary intracranial meningiomas and neurilemmomas. Arch Pathol Lab Med 104:350–354

    CAS  PubMed  Google Scholar 

  17. Schmitt HP (1984) Metastases of malignant neoplasms to intracranial tumors: the “tumor-in-a-tumor” phenomenon. Virchows Arch A Pathol Anat Histopathol 405:155–160

    Article  CAS  PubMed  Google Scholar 

  18. Aghi M, Kiehl TR, Brisman JL (2005) Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature. J Neurooncol 75:149–155

    Article  PubMed  Google Scholar 

  19. Watanabe T, Fujisawa H, Hasegawa M (2002) Metastasis of breast cancer to intracranial meningioma. Am J Clin Oncol 25:414–417

    Article  PubMed  Google Scholar 

  20. Nakajima S, Doi R, Toyoda E (2004) N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 10:4125–4133

    Article  CAS  PubMed  Google Scholar 

  21. Sakamoto A, Oda Y, Adachi T (2002) Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma. Arch Pathol Lab Med 126:1071–1078

    CAS  PubMed  Google Scholar 

  22. Azoulay S, Adem C, Pelletier FL (2005) Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin. J Cutan Pathol 32:561–566

    Article  PubMed  Google Scholar 

  23. Weiss SW, Goldblum JR (2001) Liposarcoma. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors. 4th edn. Mosby, St Louis

    Google Scholar 

  24. ten Heuvel SE, Hoeckstra HJ, Ginkel RJ (2007) Clinicopathologic prognostic factors in myxoid liposarcoma: a retrospective study of 49 patients with long-term follow-up. Ann Surg Oncol 14:222–229

    Article  PubMed  Google Scholar 

  25. Smith TA, Easly KA, Goldblum JR (1996) Myxoid/ round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of a round cell liposarcoma. Am J Surg Pathol 20:171–180

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Sisli Etfal Training and Research Hospital, M. İsmail Hakki Sk. No:10/1 Uskudar, Istanbul, 34672, Turkey

    Fevziye Kabukcuoglu, Canan Tanik & Damlanur Sakiz

  2. Department of Orthopedics and Traumatology, Taksim Training and Research Hospital, Istanbul, Turkey

    Yavuz Kabukcuoglu

  3. Department of Plastic Surgery and Reconstruction, Sisli Etfal Training and Research Hospital, Istanbul, Turkey

    Semra Karsidag

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  1. Fevziye Kabukcuoglu
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  2. Yavuz Kabukcuoglu
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  3. Canan Tanik
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  4. Damlanur Sakiz
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  5. Semra Karsidag
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Correspondence to Fevziye Kabukcuoglu.

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Kabukcuoglu, F., Kabukcuoglu, Y., Tanik, C. et al. Breast Carcinoma Metastasis in Recurrent Myxoid Liposarcoma. Pathol. Oncol. Res. 15, 467–471 (2009). https://doi.org/10.1007/s12253-008-9121-1

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  • DOI: https://doi.org/10.1007/s12253-008-9121-1

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