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Immunohistochemical Evaluation of 95 Bone Marrow Reactive Plasmacytoses

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  • Published:
Pathology & Oncology Research

Abstract

We histologically and immunohistochemically studied 95 bone marrow (BM) reactive plasmacytoses. Ten biopsies from plasma cell myeloma (PCM) patients served as a control group. In addition, we studied 10 monoclonal gammopathy of undetermined significance (MGUS) cases. Histologically, plasmacytosis varied between 5% and 25% with an interstitial pattern of plasma cell (PC) distribution being characteristically displayed. Immunohistochemically, we did not find any CD56/NCAM nor cyclin D1 expression in all biopsies (95 of 95, 100%), not even a weak, doubtful one; PCs were all polyclonal and CD138 positive. On the contrary, myeloma-associated PCs showed monoclonality for κ- or λ- light chain and strong CD56/NCAM immunoreactivity (8 of 10, 80%); four of them were cyclin D1 positive. Osteoblasts exhibited similar CD56/NCAM expression in both groups. Our data confirm the diagnostic utility of CD56/NCAM in the phenotypic characterization of polyclonal plasma cells, suggesting an important role of this particular immunomarker in the BM trephine study of polyclonal versus neoplastic plasmacytic infiltrations.

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Conflict of interest statement

We, all authors, declare no conflict of interest. It is our will so as both figures (illustrations) to be reproduced in black and white.

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  1. Thomas Papathomas

    Present address: , 12 Kerkiras Str. (Kalamaria), Thessaloniki, 55133, Greece

Authors and Affiliations

  1. Department of Pathology, Medical School, University of Thessaly, Larisa, Greece

    Maria G. Ioannou, Efstathios Stathakis, Andreas C. Lazaris, Thomas Papathomas, Evangelos Tsiambas & George K. Koukoulis

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  1. Maria G. Ioannou
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  2. Efstathios Stathakis
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Correspondence to Thomas Papathomas.

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Ioannou, M.G., Stathakis, E., Lazaris, A.C. et al. Immunohistochemical Evaluation of 95 Bone Marrow Reactive Plasmacytoses. Pathol. Oncol. Res. 15, 25–29 (2009). https://doi.org/10.1007/s12253-008-9069-1

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  • DOI: https://doi.org/10.1007/s12253-008-9069-1

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