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Human Papilloma Virus (HPV) and Host Cellular Interactions

Pathology & Oncology Research volume 14, pages 345–354 (2008)Cite this article

Abstract

Viral-induced carcinogenesis has been attributed to the ability of viral oncoproteins to target and interact with the host cellular proteins. It is generally accepted that Human papilloma virus (HPV) E6 and E7 function as the dominant oncoproteins of ‘high-risk’ HPVs by altering the function of critical cellular proteins. Initially it was shown that HPV E6 enhances the degradation of p53, while HPV E7 inactivates the function of the retinoblastoma tumor suppressor protein Rb. However, recent studies during the last decade have identified a number of additional host cellular targets of both HPV E6 and E7 that may also play an important role in malignant cellular transformation. In this review we present the interactions of HPV E6 and E7 with the host cellular target proteins. We also present the role of DNA integration in the malignant transformation of the epithelial cell.

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Abbreviations

HPV:

human papilloma virus

Rb:

retinoblastoma protein

E6-AP:

E6-associated protein

E6-BP:

E6-binding protein

hDlg:

human Drosophila discs large protein

hScrib:

human Scribble tumor suppressor protein

MAGI:

membrane-associated guanylate kinases

IRF-1 and -3:

interferon regulatory factor 1 and 3

MMP-7:

multicopy maintenance protein 7

hTERT:

human telomerase reverse transcriptase

hE6TP1:

human E6-targeted protein 1

Gps2:

G-protein pathway suppressor 2

IFNAR1:

interferon-alpha receptor 1

MUPP1:

multi-PDZ-domain protein 1

CDK:

cyclin-dependent kinases

TBP:

TATA box-binding protein

CKI and II:

casein kinase I and II

S4:

subunit 4

M2-PK:

M2 pyruvate kinase

ISGF3:

interferon-stimulated gene factor 3

IFN:

interferon

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  1. Department of Virology, School of Medicine, University of Crete, Heraklion, 71100, Crete, Greece

    Ioannis N. Mammas, George Sourvinos & Demetrios A. Spandidos

  2. Faculty of Medicine, University of Liverpool, Liverpool, UK

    Athena Giannoudis

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  1. Ioannis N. Mammas
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  2. George Sourvinos
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Mammas, I.N., Sourvinos, G., Giannoudis, A. et al. Human Papilloma Virus (HPV) and Host Cellular Interactions. Pathol. Oncol. Res. 14, 345–354 (2008). https://doi.org/10.1007/s12253-008-9056-6

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  • DOI: https://doi.org/10.1007/s12253-008-9056-6

Keywords

  • Human papilloma virus
  • HPV
  • E6
  • E7
  • Host cellular proteins
  • DNA integration