Skip to main content

Advertisement

Log in

Prion Protein Expression is Correlated with Glioma Grades

  • Letter
  • Published:
Virologica Sinica

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  • Atkinson CJ, Zhang K, Munn AL, Wiegmans A, Wei MQ (2016) Prion protein scrapie and the normal cellular prion protein. Prion 10:63–82

    Article  CAS  Google Scholar 

  • Baiardi S, Rossi M, Capellari S, Parchi P (2019) Recent advances in the histo-molecular pathology of human prion disease. Brain Pathol 29:278–300

    Article  Google Scholar 

  • Barbieri G, Palumbo S, Gabrusiewicz K, Azzalin A, Marchesi N, Spedito A, Biggiogera M, Sbalchiero E, Mazzini G, Miracco C, Pirtoli L, Kaminska B, Comincini S (2011) Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells. Autophagy 7:840–853

    Article  CAS  Google Scholar 

  • Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T (2016) Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells. Oncotarget 7:38638–38657

    Article  Google Scholar 

  • Erlich RB, Kahn SA, Lima FR, Muras AG, Martins RA, Linden R, Chiarini LB, Martins VR, Moura Neto V (2007) STI1 promotes glioma proliferation through MAPK and PI3K pathways. Glia 55:1690–1698

    Article  Google Scholar 

  • Farrell CJ, Plotkin SR (2007) Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel–Lindau, and other syndromes. Neurol Clin 25:925–946, viii

    Article  Google Scholar 

  • Fonseca AC, Romao L, Amaral RF, Assad Kahn S, Lobo D, Martins S, Marcondes de Souza J, Moura-Neto V, Lima FR (2012) Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells. Neuroscience 200:130–141

    Article  CAS  Google Scholar 

  • Goodenberger ML, Jenkins RB (2012) Genetics of adult glioma. Cancer Genet 205:613–621

    Article  CAS  Google Scholar 

  • Hirsch TZ, Martin-Lanneree S, Mouillet-Richard S (2017) Functions of the prion protein. Pro Mol Biol Transl Sci 150:1–34

    Article  CAS  Google Scholar 

  • Iglesia RP, Prado MB, Cruz L, Martins VR, Santos TG, Lopes MH (2017) Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells. Stem Cell Res Ther 8:76

    Article  CAS  Google Scholar 

  • Lathia JD, Mack SC, Mulkearns-Hubert EE, Valentim CL, Rich JN (2015) Cancer stem cells in glioblastoma. Genes Dev 29:1203–1217

    Article  CAS  Google Scholar 

  • Lawler SE (2015) Cytomegalovirus and glioblastoma; controversies and opportunities. J Neurooncol 123:465–471

    Article  CAS  Google Scholar 

  • Lopes MH, Santos TG, Rodrigues BR, Queiroz-Hazarbassanov N, Cunha IW, Wasilewska-Sampaio AP, Costa-Silva B, Marchi FA, Bleggi-Torres LF, Sanematsu PI, Suzuki SH, Oba-Shinjo SM, Marie SK, Toulmin E, Hill AF, Martins VR (2015) Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival. Oncogene 34:3305–3314

    Article  CAS  Google Scholar 

  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  Google Scholar 

  • Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64:479–489

    Article  CAS  Google Scholar 

  • Sarnataro D, Pepe A, Zurzolo C (2017) Cell Biology of Prion Protein. Prog Mol Biol Transl Sci 150:57–82

    Article  CAS  Google Scholar 

  • Xing Y, Wang Y, Wang S, Wang X, Fan D, Zhou D, An J (2016) Human cytomegalovirus infection contributes to glioma disease progression via upregulating endocan expression. Transl Res 177:113–126

    Article  CAS  Google Scholar 

  • Yang X, Zhang Y, Zhang L, He T, Zhang J, Li C (2014) Prion protein and cancers. Acta Biochim Biophys Sin (Shanghai) 46:431–440

    Article  CAS  Google Scholar 

  • Zhuang D, Liu Y, Mao Y, Gao L, Zhang H, Luan S, Huang F, Li Q (2012) TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells. Int J Cancer 130:309–318

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the following funds: the National Natural Science Foundation of China (81671971, 81871641 and 81701992) and the Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education (KZ201810025035).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Peigang Wang or Jing An.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights Statement

This study was approved by the Institutional Review Board of Beijing Tiantan Hospital, and written informed consent was obtained from all patients.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Luo, Q., Wang, Y., Fan, D. et al. Prion Protein Expression is Correlated with Glioma Grades. Virol. Sin. 35, 490–493 (2020). https://doi.org/10.1007/s12250-020-00209-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12250-020-00209-2

Navigation