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High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone

Virologica Sinica volume 34, pages 725–728 (2019)Cite this article

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References

  • Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR (1999) Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. Mol Cell Biol 19:4592–4599

    Article  CAS  Google Scholar 

  • Carvalho M, Derse D (1991) Mutational analysis of the equine infectious anemia virus Tat-responsive element. J Virol 65:3468–3474

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cook RF, Leroux C, Cook SJ, Berger SL, Lichtenstein DL, Ghabrial NN, Montelaro RC, Issel CJ (1998) Development and characterization of an in vivo pathogenic molecular clone of equine infectious anemia virus. J Virol 72:1383–1393

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cook RF, Leroux C, Issel CJ (2013) Equine infectious anemia and equine infectious anemia virus in 2013: a review. Vet Microbiol 167:181–204

    Article  CAS  Google Scholar 

  • Craigo JK, Montelaro RC (2013) Lessons in AIDS vaccine development learned from studies of equine infectious, anemia virus infection and immunity. Viruses 5:2963–2976

    Article  Google Scholar 

  • Du C, Ma J, Liu Q, Li YF, He XJ, Lin YZ, Wang XF, Meng QW, Wang X, Zhou JH (2015) Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection. Retrovirology 12:36

    Article  Google Scholar 

  • Frech K, Brack-Werner R, Werner T (1996) Common modular structure of lentivirus LTRs. Virology 224:256–267

    Article  CAS  Google Scholar 

  • He X, Shao YM, Xue F, Fan XJ, Shen RX (2003) Construction of infectious chimeric clones of equine infectious anemia virus (EIAV). Chin J Virol 19:128–132

    CAS  Google Scholar 

  • Jiang CG, Gao X, Ma J, Lin YZ, Wang XF, Zhao LP, Hua YP, Liu D, Zhou JH (2011) C-terminal truncation of the transmembrane protein of an attenuated lentiviral vaccine alters its in vitro but not in vivo replication and weakens its potential pathogenicity. Virus Res 158:235–245

    Article  CAS  Google Scholar 

  • Ma J, Wang SS, Lin YZ, Liu HF, Wei HM, Du C, Wang XF, Zhou JH (2013) An attenuated EIAV strain and its molecular clone strain differentially induce the expression of Toll-like receptors and type-I interferons in equine monocyte-derived macrophages. Vet Microbiol 166:263–269

    Article  CAS  Google Scholar 

  • Shen T, Liang H, Tong X, Fan X, He X, Ma Y, Xiang W, Shen R, Zhang X, Shao Y (2006) Amino acid mutations of the infectious clone from Chinese EIAV attenuated vaccine resulted in reversion of virulence. Vaccine 24:738–749

    Article  CAS  Google Scholar 

  • Wang XF, Lin YZ, Li Q, Liu Q, Zhao WW, Du C, Chen J, Wang X, Zhou JH (2016) Genetic evolution during the development of an attenuated EIAV vaccine. Retrovirology 13:9

    Article  Google Scholar 

  • Wang XF, Liu Q, Wang YH, Wang S, Chen J, Lin YZ, Ma J, Zhou JH, Wang X (2018) Characterization of equine infectious anemia virus long terminal repeat quasispecies in vitro and in vivo. J Virol 92:e02117–e02150

    Google Scholar 

  • Yin X, Hu Z, Gu Q, Wu X, Zheng YH, Wei P, Wang X (2014) Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol 88:1259–1270

    Article  Google Scholar 

Download references

Acknowledgements

This work is supported by grants from the National Natural Science Foundation of China (31672578 to X-F W), the Chinese Postdoctoral Science Foundation Project (2015M571386 to X-F W), and the Postdoctoral Foundation of Heilongjiang Province, China (LBH-Z14033).

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    Authors and Affiliations

    1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China

      Xue-Feng Wang & Mingxin Song

    2. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, Harbin, 150069, China

      Xue-Feng Wang, Bowen Bai, Yuezhi Lin, Ting Qi, Cheng Du & Xiaojun Wang

    Authors
    1. Xue-Feng Wang
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    2. Bowen Bai
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    7. Xiaojun Wang
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    Corresponding authors

    Correspondence to Mingxin Song or Xiaojun Wang.

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    Animal and Human Rights Statement

    Animal experiments in this study were approved by the Ethics Committees of Harbin Veterinary Research Institute (HVRI), Chinese Academy of Agricultural Sciences (CAAS).

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    Xue-Feng Wang and Bowen Bai have contributed equally to this work.

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    Wang, XF., Bai, B., Lin, Y. et al. High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone. Virol. Sin. 34, 725–728 (2019). https://doi.org/10.1007/s12250-019-00153-w

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    • DOI: https://doi.org/10.1007/s12250-019-00153-w