Genetic Analysis of an Emerging GII.P2–GII.2 Norovirus Associated with a 2016 Outbreak of Acute Gastroenteritis in China
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Noroviruses are positive-sense, single-stranded RNA viruses belonging to Caliciviridae and account for more than 50% of all acute gastroenteritis (AGE) outbreaks worldwide and cause an estimated 200,000 deaths per year among children < 5 years of age, primarily in developing countries (Hall et al.2012; Glass et al.2009). The norovirus genome contains three open reading frames (ORFs). ORF1 encodes nonstructural proteins, including an RNA-dependent RNA polymerase (RdRp), while ORF2 and ORF3 encode the major (VP1) and minor (VP2) structural proteins, respectively. Based on the sequences of their VP1 genes, noroviruses are classified into at least seven genogroups (GI–GVII) and more than 30 genotypes (Vinjé 2015). GI and GII viruses are responsible for most human infections.
Over the past 2 decades, GII.4 viruses have been the most common genotype to cause norovirus outbreaks worldwide, and new GII.4 variants have emerged approximately every 2–3 years through accumulations of...
This work was supported by the Special National Project on Research and Development of Key Biosafety Technologies (2016YFC1201900) and the National Natural Science Foundation of China (31500139).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and Human Rights Statement
This study was approved by the Institutional Review Board of the China CDC for human subject protection.
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