Virologica Sinica

, Volume 33, Issue 5, pp 456–458 | Cite as

Common Infections May Lead to Alzheimer’s Disease

  • Yuyan Wang
  • Ling Ding
  • Qing Zhu
  • Minfeng ShuEmail author
  • Qiliang CaiEmail author

Alzheimer’s disease (AD), also known as Alzheimer’s, is a chronic neurodegenerative disorder with hallmark amyloid plaques in brain tissue. The diseases commences slowly and worsens over time (Sjogren et al.1952). Although it has been investigated for over six decades, the cause of AD is still not completely understood. It was initially thought to be caused by genetic heritability (autosomal mutation leading to aggregation of β-amyloid and misfolded tau proteins) or head injury. However, hundreds of drug trials targeting the accumulation of sticky amyloid plaques and misfolded tau proteins in the brain have failed to yield any results. Although increasing evidence suggests that microbes and antimicrobial defense could play a critical role in causing AD (van den Pol 2009; Mawanda and Wallace 2013), the pathogenic microbes that contribute to AD onset and progression remain unknown.

Human herpes viruses (HHVs) are common in the brains of the elderly (Kleinschmidt-DeMasters and Gilden 2001...



We thank all members in the lab for critical reading and discussion. This work was supported by the National Key Research and Development Program of China (2016YFC1200400). QC is a scholar of New Century Excellent Talents in University of China.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and Human Rights Statement

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.MOE & MOH Key Laboratory of Medical Molecular Virology, School of Basic MedicineShanghai Medical College, Fudan UniversityShanghaiChina

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