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KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China

Virologica Sinica volume 33, pages 369–372 (2018)Cite this article

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References

  • Asselah T (2012) A revolution in hcv treatment with direct-acting antivirals: from non-response to eradication. J Hepatol 57:455–457

    Article  PubMed  Google Scholar 

  • Bashirova AA, Martin MP, McVicar DW, Carrington M (2006) The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet 7:277–300

    Article  PubMed  CAS  Google Scholar 

  • Bunce M, O’Neill CM, Barnardo MC, Krausa P, Browning MJ, Morris PJ, Welsh KI (1995) Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46:355–367

    Article  PubMed  CAS  Google Scholar 

  • Carneiro VL, Lemaire DC, Bendicho MT, Souza SL, Cavalcante LN, Angelo AL, Freire SM, Mendes CM, Santana N, Lyra LG, Lyra AC (2010) Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders. Liver Int 30:567–573

    Article  PubMed  CAS  Google Scholar 

  • Chinese Society of Hepatology CMA, Wei L, Chinese Society of Infectious Diseases CMA, Hou JL (2015) The guideline of prevention and treatment for hepatitis C: a 2015 update. Zhonghua Gan Zang Bing Za Zhi 23:906–923

    Google Scholar 

  • de Vasconcelos JM, de Jesus Maues Pereira Moia L, Amaral IS, Miranda EC, Cicalisetakeshita LY, de Oliveira LF, de Araujo Melo Mendes L, Sastre D, Tamegao-Lopes BP, de Aquino Pedroza LS, Batista Dos Santos SE, Soares MC, de Araujo MT, Bandeira CL, de Sousa da Silva AM, de Medeiros ZL, Sena L, Demachki S, Dos Santos EJ (2013) Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis c and responses to therapy in Brazil. Genet Mol Biol 36:22–27

    Article  PubMed  PubMed Central  Google Scholar 

  • Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R, Irish HCVRC, O’Farrelly C, Gardiner CM (2011) Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Proc Natl Acad Sci U S A 108:5736–5741

    Article  PubMed  PubMed Central  Google Scholar 

  • Du Z, Gjertson DW, Reed EF, Rajalingam R (2007) Receptor-ligand analyses define minimal killer cell ig-like receptor (KIR) in humans. Immunogenetics 59:1–15

    Article  PubMed  CAS  Google Scholar 

  • Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr, Haussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A, Lin A, Hoffman J, Yu J (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347:975–982

    Article  PubMed  CAS  Google Scholar 

  • Gebo KA, Bartlett JG (2002) Management of hepatitis C: a review of the NIH consensus development conference. Hopkins HIV Rep 14:1–4

    Google Scholar 

  • Hsu KC, Liu XR, Selvakumar A, Mickelson E, O’Reilly RJ, Dupont B (2002) Killer ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol 169:5118–5129

    Article  PubMed  Google Scholar 

  • Parham P (2005) MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5:201–214

    Article  PubMed  CAS  Google Scholar 

  • Robinson J, Waller MJ, Parham P, de Groot N, Bontrop R, Kennedy LJ, Stoehr P, Marsh SG (2003) IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res 31:311–314

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Single RM, Martin MP, Gao X, Meyer D, Yeager M, Kidd JR, Kidd KK, Carrington M (2007) Global diversity and evidence for coevolution of KIR and HLA. Nat Genet 39:1114–1119

    Article  PubMed  CAS  Google Scholar 

  • Vidal-Castineira JR, Lopez-Vazquez A, Diaz-Pena R, Alonso-Arias R, Martinez-Borra J, Perez R, Fernandez-Suarez J, Melon S, Prieto J, Rodrigo L, Lopez-Larrea C (2010) Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection. J Virol 84:475–481

    Article  PubMed  CAS  Google Scholar 

  • Vidal-Castineira JR, Lopez-Vazquez A, Martinez-Borra J, Martinez-Camblor P, Prieto J, Lopez-Rodriguez R, Sanz-Cameno P, de la Vega J, Rodrigo L, Perez-Lopez R, Perez-Alvarez R, Lopez-Larrea C (2014) Diversity of killer cell immunoglobulin-like receptor (KIR) genotypes and KIR2DL2/3 variants in HCV treatment outcome. PLoS ONE 9:e99426

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zwolinska K, Blachowicz O, Tomczyk T, Knysz B, Gasiorowski J, Zalewska M, Orzechowska BU, Sochocka M, Piasecki E (2016) The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the polish population. Immunogenetics 68:327–337

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgements

We thank all subjects who donated samples for this study. This work was supported by Grants from the National Major Science and Technology Project for Infectious Diseases of China (2012ZX10004503), and Major State Basic Research Development Program of China (973 Program; No. 2013CB530505).

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Authors and Affiliations

  1. Medical College, Jianghan University, Wuhan, 430056, China

    Song Hu, Fahu Yuan, Lingyan Feng & Binlian Sun

  2. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Fang Zheng & Feili Gong

  3. Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Hanju Huang

Authors
  1. Song Hu
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  2. Fahu Yuan
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  3. Lingyan Feng
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  6. Hanju Huang
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Corresponding author

Correspondence to Binlian Sun.

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The authors declare that they have no conflicts of interest.

Animal and Human Rights Statement

This study conformed to the 1975 Declaration of Helsinki guidelines and permission was obtained from the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology. Prior to the study, informed consent was obtained from each individual.

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Hu, S., Yuan, F., Feng, L. et al. KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China. Virol. Sin. 33, 369–372 (2018). https://doi.org/10.1007/s12250-018-0042-1

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  • DOI: https://doi.org/10.1007/s12250-018-0042-1