N-Terminal Myristoylated VP5 is Required for Penetrating Cell Membrane and Promoting Infectivity in Aquareoviruses
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Myristoylation is a naturally occurring post-translational modification for targeting cytoplasmic proteins to intracellular membranes. Unlike enveloped animal viruses, which enter host cells by membrane fusion, nonenveloped animal viruses must disrupt the cell membrane to initiate infection. Some animal viruses and several nonenveloped viruses such as reovirus and poliovirus were shown to contain myristoylated structural proteins (Ivanovic et al. 2008).
Aquareovirus spp., belonging to the Reoviridae family, infect several aquatic animals, including fish, shellfish, and mollusks. Generally, aquareoviruses show low pathogenicity in aquatic cultures and are identified during routine examination. Grass carp reovirus (GCRV), which causes severe hemorrhagic disease in grass carp fingerlings and yearlings, is considered as one of the most important pathogens (Rangel et al. 1999). Similar to other reoviruses, GCRV consists of an 11-segment dsRNA genome core surrounded by a...
This work is supported in part by grants from the National Natural Science Foundation of China (31672693, 31372565, 31172434).
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The authors declare that they have no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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