Virologica Sinica

, Volume 33, Issue 2, pp 209–212 | Cite as

Characteristics of HIV-1 Molecular Epidemiology in Suzhou, China, from 2009 to 2014

  • Ying Yuan
  • Shengjie Tang
  • Yuan Li
  • Dongmei Yan
  • Qunxin Peng
  • Xuerong YaEmail author
  • Yanhui SongEmail author

Dear Editor,

Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) remain major public health problems in China, where approximately 780,000 people currently live with HIV, according to the 2012 China AIDS Response Progress Report. Suzhou was an early epidemic region in Jiangsu province and the current situation of HIV-1 prevalence is complicated. In the late 1980s, a labor force returning to Suzhou from Asia and Africa contributed to an early HIV-1 epidemic in the region. The first case of HIV-1 in Suzhou was identified by a sexually transmitted disease clinic in 1992 (Xia et al.1993). Suzhou later attracted migrant populations, complicating the HIV-1 subtypes circulating in the region. In 1998, an immigrant from Xinjiang province was diagnosed as the first case of HIV-1 acquired by intravenous injection in Suzhou (Shao et al.1999a). According to HIV epidemic surveillance data collected in Jiangsu province since 2011, Suzhou is now one of five cities in...



We gratefully acknowledge the contribution of the HIV-1 patients who participated in this study and also wish to thank the staff of the local CDC for recruiting participants, collecting samples, and technical assistance. This work was supported by grants from the Open Research Fund Program of the State Key Laboratory of Virology of China (2017IOV003), the Health Department of Jiangsu Province (Y2013062), and Suzhou Science Technology Bureau (SYS201452) and in part by grants from the National Science Foundation of China (NSFC) (81101257) and the Natural Science Foundation of Heilongjiang Province (H201355).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Animal and human rights statement

Animal and Human Rights Statement was obtained from all patients for whom identifying information is included in this article.

Supplementary material

12250_2018_22_MOESM1_ESM.pdf (435 kb)
Supplementary material 1 (PDF 173 kb)


  1. An M, Han X, Xu J, Chu Z, Jia M, Wu H, Lu L, Takebe Y, Shang H (2012) Reconstituting the epidemic history of HIV strain CRF01_AE among men who have sex with men (MSM) in Liaoning, northeastern China: implications for the expanding epidemic among MSM in China. J Virol 86:12402–12406CrossRefPubMedPubMedCentralGoogle Scholar
  2. Ding J, Xu J, Huan X, Liu X, Fu G, Wang X, Qiu T, Xu X, Yang H (2012) Analysis of AIDS epidemic in 2011 in Jiangsu Province. Jiangsu J Prev Med 5:34–35 (in Chinese) Google Scholar
  3. Fu Z, Zhao X, Zhao Y, Cao X, Zhang F, Shao M (2013) The AIDS epidemic analysis in Suzhou from 2005–2012. Jiangsu J Prev Med 24:48–49 (in Chinese) Google Scholar
  4. Fu Z, Zhao X, Cao X, Zhao Y, Zhang F, Shao M (2014) HIV incidence among men who have sex with men in Suzhou city: a cohort study. Chin J Public Health 30:726–728 (in Chinese) Google Scholar
  5. He Q, Wang Y, Lin P, Liu Y, Yang F, Fu X, Li Y, Sun B, Li J, Zhao X, Mandel J, Jain S, McFarland W (2006) Potential bridges for HIV infection to men who have sex with men in Guangzhou, China. AIDS Behav 10:S17–S23CrossRefPubMedGoogle Scholar
  6. He X, Xing H, Ruan Y, Hong K, Cheng C, Hu Y, Xin R, Wei J, Feng Y, Hsi JH, Takebe Y, Shao Y, Group for HIVMES (2012) A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey. PLoS ONE 7:e47289CrossRefPubMedPubMedCentralGoogle Scholar
  7. Liao L, Xing H, Li X, Ruan Y, Zhang Y, Qin G, Shao Y (2007) Genotypic analysis of the protease and reverse transcriptase of HIV type 1 isolates from recently infected injecting drug users in western China. AIDS Res Hum Retroviruses 23:1062–1065CrossRefPubMedGoogle Scholar
  8. Ng KT, Ng KY, Khong WX, Chew KK, Singh PK, Yap JK, Tan MT, Leo YS, Laeyendecker O, Quinn TC, Kamarulzaman A, Tee KK, Ng OT (2013) Phylodynamic profile of HIV-1 subtype B, CRF01_AE and the recently emerging CRF51_01B among men who have sex with men (MSM) in Singapore. PLoS ONE 8:e80884CrossRefPubMedPubMedCentralGoogle Scholar
  9. Qin C, Zhang P, Zhu W, Hao F, Gu A, Fen P, Zhu X, Du H (2016) HIV-1 diversity in infected individuals in Suzhou and Suqian, China. SpringerPlus 5:886CrossRefPubMedPubMedCentralGoogle Scholar
  10. Shao M, Shi S, Zhang H, Liu C (1999a) The first HIV-1 infection case report in foreign durg users in Suzhou. J Handan Med College 12:364 (in Chinese) Google Scholar
  11. Shao Y, Zhao F, Yang W (1999b) The identification of recombinant HIV-1 strains in IDUs in southwest and northwest China. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 13:109–112 (in Chinese) PubMedGoogle Scholar
  12. Song YH, Meng ZF, Xing H, Ruan YH, Li XP, Xin RL, Ma PF, Peng H, Shao Y (2007) Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6. Arch Virol 152:1553–1558CrossRefPubMedGoogle Scholar
  13. Stoeckli TC, Steffen-Klopfstein I, Erb P, Brown TM, Kalish ML (2000) Molecular epidemiology of HIV-1 in Switzerland: evidence for a silent mutation in the C2V3 region distinguishing intravenous drug users from homosexual men. Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 23:58–67CrossRefPubMedGoogle Scholar
  14. Sun YM, Sun WD, Lu HY, Xin RL, He SF, Zhang Q, Yue H, Fan XG, Ma XY (2016) Surveillance for HIV infection in MSM selected through respondent driven sampling in Beijing, 2005-2012. Zhonghua Liu Xing Bing Xue Za Zhi 37:1383–1391 (in Chinese) PubMedGoogle Scholar
  15. Xia J, Wu W, Min X, Shi S, Yang H (1993) The investigation of first AIDS patient in Suzhou Shanghai. J Prev Med 5:23 (in Chinese) Google Scholar
  16. Zhao Y, Cao X, Zhan F (2005) The HIV/AIDS Survey in Suzhou from 1992-2004. Dis Surveill 20:123–124 (in Chinese) Google Scholar

Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Clinical Laboratory, The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhouChina
  2. 2.The Institutes of Biological and Medical SciencesSoochow UniversitySuzhouChina
  3. 3.Basic Medical College of Jiamusi UniversityJiamusi UniversityJiamusiChina
  4. 4.Suzhou Center for Disease Control and PreventionSuzhouChina

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