Virologica Sinica

, Volume 33, Issue 1, pp 108–110 | Cite as

Genomic Characterization of a Novel Hepatovirus from Great Roundleaf Bats in China

  • Wen Li
  • Bo Wang
  • Bei Li
  • Wei Zhang
  • Yan Zhu
  • Zheng-Li Shi
  • Xing-Lou Yang

Dear Editor,

The hepatitis A virus (HAV) is a common agent causing acute liver disease worldwide, with approximately 11,000 deaths annually (WHO 2017). The virus is transmitted primarily by the fecal-oral route and it normally infects people living in high-density and resource-poor countries (Aggarwal and Goel 2015). Epidemics may also occur after the accidental introduction of HAV to areas with better sanitation but susceptible population (Jacobsen and Wiersma 2010). HAV is a positive-sense, single-stranded RNA virus of the genus Hepatovirus in the family Picornaviridae (Adams et al. 2017). The genome is approximately 7500 nucleotides in length and contains a single open reading frame (ORF) encoding a polyprotein, which is divided into three regions: P1 (VP1–VP4, constituting the viral capsid), P2 (2A–2C), and P3 (3A–3D, constituting the polymerase) (Hollinger and Martin 2013). HAV has been classified as the type species of Hepatovirus (HepV), and historically humans and other...



This work was jointly funded by the National Natural Science Foundation of China (Grant No. 81290341). We also thank The Core Facility and Technical Support, Wuhan Institute of Virology for assistance in high throughput sequencing sample preparation.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and human rights statement

This study was approved by the Animal Ethics Committee of the Wuhan Institute of Virology (Animal ethics Approval Number: WIVA05201202).

Supplementary material

12250_2018_13_MOESM1_ESM.pdf (739 kb)
Supplementary material 1 (PDF 740 kb)


  1. Adams MJ, Lefkowitz EJ, King AMQ, Harrach B, Harrison RL, Knowles NJ, Kropinski AM, Krupovic M, Kuhn JH, Mushegian AR, Nibert M, Sabanadzovic S, Sanfacon H, Siddell SG, Simmonds P, Varsani A, Zerbini FM, Gorbalenya AE, Davison AJ (2017) Changes to taxonomy and the international code of virus classification and nomenclature ratified by the international committee on taxonomy of viruses. Arch Virol 162:2505–2538CrossRefPubMedGoogle Scholar
  2. Aggarwal R, Goel A (2015) Hepatitis a: epidemiology in resource-poor countries. Curr Opin Infect Dis 28:488–496CrossRefPubMedGoogle Scholar
  3. Aragones L, Guix S, Ribes E, Bosch A, Pinto RM (2010) Fine-tuning translation kinetics selection as the driving force of codon usage bias in the hepatitis a virus capsid. PLoS Pathog 6:e1000797CrossRefPubMedPubMedCentralGoogle Scholar
  4. Dienstag JL, Davenport FM, McCollum RW, Hennessy AV, Klatskin G, Purcell RH (1976) Nonhuman primate-associated viral hepatitis type a. Serologic evidence of hepatitis a virus infection. JAMA 236:462–464CrossRefPubMedGoogle Scholar
  5. Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brunink S, Rasche A, Seggewibeta N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C, Hepatovirus Ecology C (2015) Evolutionary origins of hepatitis a virus in small mammals. Proc Natl Acad Sci USA 112:15190–15195CrossRefPubMedPubMedCentralGoogle Scholar
  6. He B, Zhang F, Xia L, Hu T, Chen G, Qiu W, Fan Q, Feng Y, Guo H, Tu C (2015) Identification of a novel orthohepadnavirus in pomona roundleaf bats in china. Arch Virol 160:335–337CrossRefPubMedGoogle Scholar
  7. Hollinger FB, Martin A (2013) Hepatitis a virus. In: Kluwer W (ed) Field’s virology, vol 6. Lippincott Williams & Wilkins, Philadelphia, pp 550–581Google Scholar
  8. Jacobsen KH, Wiersma ST (2010) Hepatitis a virus seroprevalence by age and world region, 1990 and 2005. Vaccine 28:6653–6657CrossRefPubMedGoogle Scholar
  9. Nie FY, Lin XD, Hao ZY, Chen XN, Wang ZX, Wang MR, Wu J, Wang HW, Zhao G, Ma RZ, Holmes EC, Zhang YZ (2017) Extensive diversity and evolution of hepadnaviruses in bats in china. Virology 514:88–97CrossRefPubMedGoogle Scholar
  10. Shi Z (2013) Emerging infectious diseases associated with bat viruses. Sci China Life Sci 56:678–682CrossRefPubMedGoogle Scholar
  11. Wang B, Yang XL, Li W, Zhu Y, Ge XY, Zhang LB, Zhang YZ, Bock CT, Shi ZL (2017) Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in china. Virol J 14:40CrossRefPubMedPubMedCentralGoogle Scholar
  12. WHO (2017) Global hepatitis report 2017. World Health Organization. Accessed 23 Nov 2017
  13. Yu JM, Li LL, Zhang CY, Lu S, Ao YY, Gao HC, Xie ZP, Xie GC, Sun XM, Pang LL, Xu JG, Lipkin WI, Duan ZJ (2016) A novel hepatovirus identified in wild woodchuck marmota himalayana. Sci Rep 6:22361CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina

Personalised recommendations