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Virologica Sinica

, Volume 33, Issue 1, pp 108–110 | Cite as

Genomic Characterization of a Novel Hepatovirus from Great Roundleaf Bats in China

  • Wen Li
  • Bo Wang
  • Bei Li
  • Wei Zhang
  • Yan Zhu
  • Zheng-Li Shi
  • Xing-Lou Yang
Letter

Dear Editor,

The hepatitis A virus (HAV) is a common agent causing acute liver disease worldwide, with approximately 11,000 deaths annually (WHO 2017). The virus is transmitted primarily by the fecal-oral route and it normally infects people living in high-density and resource-poor countries (Aggarwal and Goel 2015). Epidemics may also occur after the accidental introduction of HAV to areas with better sanitation but susceptible population (Jacobsen and Wiersma 2010). HAV is a positive-sense, single-stranded RNA virus of the genus Hepatovirus in the family Picornaviridae (Adams et al. 2017). The genome is approximately 7500 nucleotides in length and contains a single open reading frame (ORF) encoding a polyprotein, which is divided into three regions: P1 (VP1–VP4, constituting the viral capsid), P2 (2A–2C), and P3 (3A–3D, constituting the polymerase) (Hollinger and Martin 2013). HAV has been classified as the type species of Hepatovirus (HepV), and historically humans and other...

Notes

Acknowledgements

This work was jointly funded by the National Natural Science Foundation of China (Grant No. 81290341). We also thank The Core Facility and Technical Support, Wuhan Institute of Virology for assistance in high throughput sequencing sample preparation.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Animal and human rights statement

This study was approved by the Animal Ethics Committee of the Wuhan Institute of Virology (Animal ethics Approval Number: WIVA05201202).

Supplementary material

12250_2018_13_MOESM1_ESM.pdf (739 kb)
Supplementary material 1 (PDF 740 kb)

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Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina

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