Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine
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In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in Guangdong Province, China, infected more than 8000 individuals, and resulted in a 10% mortality rate (Rota et al.2003). Later, in 2012, a novel CoV, Middle East respiratory syndrome coronavirus (MERS-CoV), was isolated from the sputum of a man in Saudi Arabia (Perl et al.2014). Notably, MERS-CoV recently reemerged in the Republic of Korea, and killed 36 out of 186 confirmed cases (Korea Centers for Disease Control and Prevention 2015). Therefore, SARS-CoV still carries the potential for resurgence; efforts are being made to prevent the recurrence of an epidemic.
Currently, effective antiviral strategies to control SARS-CoV infections are lacking; vaccination is still regarded as the major approach for preventing SARS and related diseases. Generally, virus-specific antibodies play important roles in the control of viral infections. However, the presence of specific antibodies can be beneficial for...
This work was supported by the Chinese Medicine Foundation and Opening Foundation of State Key Laboratory of Virology, Wuhan University (No. 2016KF010).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest to disclose.
Animal and Human Rights Statement
All of the study protocols and procedures were approved by the Institutional Animal Care and Use Committee of Wuhan University.
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