Skip to main content

NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3

Virologica Sinica volume 33, pages 205–208 (2018)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1

References

  • Attia M, Forster A, Rachez C, Freemont P, Avner P, Rogner UC (2011) Interaction between nucleosome assembly protein 1-like family members. J Mol Biol 407:647–660

    Article  CAS  PubMed  Google Scholar 

  • Cevik RE, Cesarec M, Da Silva Filipe A, Licastro D, McLauchlan J, Marcello A (2017) Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response. J Virol 91(18):e00880

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M (2017) Phosphorylation of serine 225 in hepatitis C virus NS5A regulates protein–protein interactions. J Virol 91(17):e00805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gupta N, Thakker S, Verma SC (2016) KSHV encoded LANA recruits nucleosome assembly protein NAP1L1 for regulating viral DNA replication and transcription. Sci Rep 6:32633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee JY, Lake RJ, Kirk J, Bohr VA, Fan HY, Hohng S (2017) NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucl Acids Res 45:4696–4707

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, Xiao Y, Chen L, Chung RT, Zhang L (2014) Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. J Virol 88:5956–5966

    Article  PubMed  PubMed Central  Google Scholar 

  • Moradpour D, Penin F, Rice CM (2007) Replication of hepatitis C virus. Nat Rev Microbiol 5:453–463

    Article  CAS  PubMed  Google Scholar 

  • Moshkin YM, Moshkin YM, Kan TW, Goodfellow H, Bezstarosti K, Maeda RK, Pilyugin M, Karch F, Bray SJ, Demmers JA, Verrijzer CP (2009) Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Mol Cell 35:782–793

    Article  CAS  PubMed  Google Scholar 

  • Rehtanz M, Schmidt HM, Warthorst U, Steger G (2004) Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol 24:2153–2168

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sharma N, Nyborg JK (2008) The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter. Proc Natl Acad Sci USA 105:7959–7963

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vardabasso C, Manganaro L, Lusic M, Marcello A, Giacca M (2008) The histone chaperone protein nucleosome assembly protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. Retrovirology 5:8

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang S, Frappier L (2009) Nucleosome assembly proteins bind to Epstein–Barr virus nuclear antigen 1 and affect its functions in DNA replication and transcriptional activation. J Virol 83:11704–11714

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yin P, Hong Z, Yang X, Chung RT, Zhang L (2016) A role for retromer in hepatitis C virus replication. Cell Mol Life Sci 73:869–881

    Article  CAS  PubMed  Google Scholar 

  • Zhang N, Yin P, Zhou L, Li H, Zhang L (2016) ARF1 activation dissociates ADRP from lipid droplets to promote HCV assembly. Biochem Biophys Res Commun 475:31–36

    Article  CAS  PubMed  Google Scholar 

  • Zlatanova J, Seebart C, Tomschik M (2007) Nap1: taking a closer look at a juggler protein of extraordinary skills. FASEB J 21:1294–1310

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the Beijing Natural Science Foundation (7164283), National Natural Science Foundation of China (81471955, 81672035), PUMC youth Fund (3332016085), the Fundamental Research Funds for the Central Universities, CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-020), and Program for Changjiang Scholars and Innovative Research Team in University (IRT13007). We thank Charles Rice, Francis Chisari, Ping Zhao, Masanori Ikeda, Nobuyuki Kato and Takaji Wakita for reagents.

Author information

Author notes

  1. Peiqi Yin and Ye Li have contributed equally to this work.

Authors and Affiliations

  1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100176, China

    Peiqi Yin, Ye Li, Liya Zhou & Leiliang Zhang

Authors
  1. Peiqi Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ye Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liya Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Leiliang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Leiliang Zhang.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Animal and Human Rights Statement

This article does not contain any studies with human or animal subjects performed by any of the authors.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yin, P., Li, Y., Zhou, L. et al. NAP1L1 Regulates Hepatitis C Virus Entry and Interacts with NS3. Virol. Sin. 33, 205–208 (2018). https://doi.org/10.1007/s12250-018-0006-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12250-018-0006-5