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Prevalence of Kaposi’s sarcoma-associated herpesvirus among intravenous drug users: a systematic review and meta-analysis

Virologica Sinica volume 32, pages 415–422 (2017)Cite this article

Abstract

Intravenous drug users (IDUs) have been demonstrated to be highly vulnerable to HIV/AIDS. Nevertheless, the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV), an important co-infected agent with HIV, among this population remained obscure. We conducted a systematic review on the epidemiological features of KSHV among IDUs worldwide. Eligible studies were retrieved from 6 electronic databases (PubMed, EMBASE, Web of Science, CBM, CNKI and Wanfang). We calculated the pooled prevalence and 95% confidence interval (CI) overall and among subgroups using either random-effects model or fixed-effects model depending on between-study heterogeneity. The potential publication bias was assessed by the Egger’s test. A meta-regression analysis was performed to explore the sources of heterogeneity. Finally, twenty-two studies with a total sample of 7881 IDUs were included in the analysis. The pooled prevalence of KSHV was 14.71% (95% CI 11.12%–19.46%) among IDUs. Specifically, KSHV prevalence was 10.86% (95% CI 6.95%–16.96%) in HIV-negative IDUs, and 13.56% (95% CI 10.57%–17.38%) in HIV-positive IDUs. Moreover, prevalence among IDUs from the three continents involved in the current study was similar: 16.10% (95%CI 7.73%–33.54%) in Asia; 14.22% (95%CI 8.96%–22.57%) in Europe and 14.06% (95%CI 11.38%–17.37%) in America. Globally, IDUs are at higher risk of the KSHV infection when compared with the general population, regardless of geographical region or HIV-infection status.

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Acknowledgments

This work was supported by the Natural Science Foundation of Shanghai (17ZR1401400), the Natural Science Foundation of China (grant no. 81772170, U603117) and the Doctoral Fund of Ministry of Education of China (Grant No. 20120071120050).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China

    Qiwen Fang, Zhenqiu Liu, Zhijie Zhang & Tiejun Zhang

  2. Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, 200032, China

    Qiwen Fang

  3. Department of Biochemistry and Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832002, China

    Yan Zeng

  4. Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, 200032, China

    Tiejun Zhang

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  1. Qiwen Fang
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Correspondence to Yan Zeng or Tiejun Zhang.

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Prevalence of kaposi’s sarcoma-associated herpesvirus among intravenous drug users: a systematic review and meta-analysis

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Fang, Q., Liu, Z., Zhang, Z. et al. Prevalence of Kaposi’s sarcoma-associated herpesvirus among intravenous drug users: a systematic review and meta-analysis. Virol. Sin. 32, 415–422 (2017). https://doi.org/10.1007/s12250-017-4051-2

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Keywords

  • Kaposi’s sarcoma-associated herpesvirus (KSHV)
  • prevalence
  • intravenous drug users (IDUs)