Virologica Sinica

, Volume 32, Issue 5, pp 396–403 | Cite as

Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

  • Jun Zheng
  • Yang Yang
  • Meng Cui
  • Zhan-Jun Shu
  • Li-Li Han
  • Zhen-Qiu Liu
  • Charles Wood
  • Tiejun Zhang
  • Yan Zeng
Open Access
Research Article
  • 27 Downloads

Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.

Keywords

Kaposi’s sarcoma associated herpesvirus (KSHV) prevalence Uygur ethnicity Han ethnicity Xinjiang 

Supplementary material

12250_2017_4049_MOESM1_ESM.pdf (456 kb)
Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China

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Copyright information

© Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Key Laboratory of Xinjiang Endemic and Ethnic Disease & Department of Biochemistry, School of MedicineShihezi UniversityShiheziChina
  2. 2.Department of Stomatology, The First Affiliated Hospital, School of MedicineShihezi UniversityShiheziChina
  3. 3.Division of AIDS ResearchNational Traditional Chinese Medicine Clinical Research Bases in XinjiangUrumqiChina
  4. 4.Department of GynecologyXinjiang Uygur Autonomous Region People’s HospitalUrumqiChina
  5. 5.Department of Epidemiology, School of Public HealthFudan UniversityShanghaiChina
  6. 6.Nebraska Center of Virology and the School of Biological SciencesUniversity of Nebraska-LincolnLincolnUSA

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