Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication

  • Huixia Zhang
  • Shanshan Gao
  • Rongjuan Pei
  • Xinwen Chen
  • Chaoyang Li
Research Article
  • 48 Downloads

Abstract

Hepatitis C virus (HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein (PrP) was induced in an HCV replication cell model. We then showed that increased PrP expression facilitated HCV genomic replication. Finally, we demonstrated that the KKRPK motif on the N-terminus of PrP bound nucleic acids and facilitated HCV genomic replication. Our results provided important insights into how viruses may harness cellular protein to achieve propagation.

Keywords

hepatitis C virus (HCV) NS3 NS5B prion protein (PrP) 

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Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.State Key Laboratory of VirologyChinese Academy of SciencesWuhanChina
  2. 2.Center for Molecular Virology, Wuhan Institute of VirologyChinese Academy of SciencesWuhanChina
  3. 3.University of the Chinese Academy of SciencesBeijingChina

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