Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis

Review

Abstract

Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors. To date, the precise role of cellular lipids and lipid metabolism in viral oncogenesis is still largely unclear with only a handful of literature covering this topic to implicate lipid metabolism in oncogenic virus associated pathogenesis. In this review, we focus on the role of lipid biosynthesis and metabolism in the pathogenesis of the Kaposi’s sarcoma-associated herpesvirus, a common causative factor for cancers arising in the immunocompromised settings.

Keywords

Kaposi’s sarcoma-associated herpesvirus (KSHV) herpesvirus lipid metabolism 

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Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of GeneticsLouisiana State University Health Sciences Center, Louisiana Cancer Research CenterNew OrleansUSA
  2. 2.Department of Pediatrics, East HospitalTongji University School of MedicineShanghaiChina
  3. 3.Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East HospitalTongji University School of MedicineShanghaiChina
  4. 4.Department of PathologyTulane University Health Sciences Center, Tulane Cancer CenterNew OrleansUSA
  5. 5.Department of Microbiology and Immunology, Division of Infectious Diseases, Department of MedicineMedical University of South CarolinaCharlestonUSA

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