Virologica Sinica

, Volume 32, Issue 6, pp 533–536 | Cite as

Interplay between hepatitis C virus and ARF4

  • Na Zhang
  • Youyang Ke
  • Leiliang Zhang


In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.


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Copyright information

© Wuhan Institute of Virology, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of Emergency171st Hospital of PLAJiujiangChina

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